34841-47-9

Basic information

• Product Name: 2-(4-Formylphenyl)acetic acid
• Synonyms: 2-(4-Formylphenyl)acetic acid;4-Formylbenzeneacetic acid;Benzeneacetic acid, 4-forMyl-;4-carboxymethyl benzaldehyde
• CAS NO: 34841-47-9
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.15802
• Mol File: 34841-47-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 131 °C
• Boiling Point: 349.2±17.0 °C(Predicted)
• Appearance: /
• Density: 1.277±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.06±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Formylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Formylphenyl)acetic acid(34841-47-9)
• EPA Substance Registry System: 2-(4-Formylphenyl)acetic acid(34841-47-9)

Safety Data

• Hazardous Substances Data: 34841-47-9(Hazardous Substances Data)

Usage

General Description

2-(4-Formylphenyl)acetic acid is a chemical compound with a molecular formula C9H8O3. It is a carboxylic acid derivative, specifically an aromatic acetic acid, with a formyl group attached to the phenyl ring. 2-(4-Formylphenyl)acetic acid is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It can be prepared through the reaction of 4-bromotoluene with potassium cyanide followed by hydrolysis to yield 2-(4-Formylphenyl)acetic acid. Its chemical properties make it a versatile building block for the production of a wide range of materials in the chemical and pharmaceutical industries.

Upstream product

• 96524-70-8 methyl 2-(4-formylphenyl)acetate 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 333389-49-4 4-(2-(ethoxycarbonyl)vinyl)phenylacetic acid 
• 7529-22-8 4-methylmorpholine N-oxide 
• 622-47-9 4-tolylacetic acid 
• 13737-36-5 4-bromophenylacetic acid 
• 5462-71-5 4-cyanophenylacetic acid 
• 73401-74-8 4-hydroxymethylphenylacetic acid 
• 43153-12-4 ethyl 2-(4-formylphenyl)acetate 

Downstream Products

• 154349-03-8 (E)-2-[4-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl]acetic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 1057854-36-0 C₂₂H₁₉N₃O₃ 
• 105-07-7 4-cyanobenzaldehyde 

Relevant articles and documents

Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase

A series of C4-substituted tertiary nitrogen-bearing 2′-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2′-hydroxychalcone analogues displayed a better inhibition against acetyl

An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides

A Mo(CO)6 (molybdenumhexacarbonyl) catalyzed reductive functionalization of amides to afford 5-amino substituted 4,5-dihydroisoxazoles is presented. The reduction of amides generates reactive enamines, which upon the addition of hydroximinoyl chlorides and base undergoes a 1,3-dipolar cycloaddition reaction that gives access to the desired heterocyclic compounds. The transformation of amides is highly chemoselective and tolerates functional groups such as nitro, nitriles, esters, and ketones. Furthermore, a versatile scope of 4,5-dihydroisoxazoles derived from a variety of hydroximinoyl chlorides and amides is demonstrated. (Figure presented.).

Method for synthesizing aromatic aldehyde, aromatic ketone and aromatic ester through catalytically oxidizing alkyl aromatic compound by iron

The invention discloses a method for synthesizing aromatic aldehyde, aromatic ketone and aromatic ester through catalytically oxidizing an alkyl aromatic compound by iron, and belongs to the technical field of catalytic synthesis. According to the method, a low-cost and environment-friendly iron catalyst is used under a normal pressure; under the action of hydrogen and silicon reagents serving as an accelerant and an oxidant, a side chain of an aromatic hydrocarbon is oxidized into a carbonyl group for generating the corresponding aromatic aldehyde, aromatic ketone and aromatic ester. The method for preparing the aromatic aldehyde, the aromatic ketone and the aromatic ester through a catalytic oxidation reaction, which is provided by the invention, has numerous advantages that a catalyst, reaction raw materials, the oxidant and a silicon reagent are wide in sources and good in stability and is low-cost and environment-friendly; the alkyl aromatic compound is metered to participate in a reaction; the reaction condition is mild; the compatibility of functional groups is good; the scope of application is wide; the reaction selectivity is good; in an optimized reaction condition, the separation yield of a target product can be up to approximately 95 percent.