3485-84-5Relevant articles and documents
Synthesis and biological properties of novel structural analogs of isothiobarbamine
Bakulin, D. A.,Brunilina, L. L.,Chapurkin, V. V.,Kovalev, N. S.,Kurkin, D. V.,Nawrozkij, M. B.,Novakov, I. A.,Ruchko, E. A.,Sablina, L. A.,Salykin, N. A.,Sheikin, D. S.,Tyurenkov, I. N.,Vernigora, A. A.,Vorontsov, M. Yu.,Vostrikova, O. V.
, p. 2220 - 2226 (2022/01/22)
Novel structural analogs of isothiobarbamine, which differ from the prototype scaffold by the substituent at position 2 of the pyrimidine heterocycle, were for the first time synthesized and characterized. Data acquired in pharmacological experiments in vivo revealed that compounds 1b—d and 10 increase physical productivity, whereas compounds 1c and 10 exhibit a nootropic effect, compound 8a shows a psychostimulating effect, and compound 1b exhibits anxiolytic properties. The results reported herein indicate that the drug discovery based on new structural analogs of isothiobarbamine is promising since it may lead to drugs for the prevention and treatment of asthenia (chronic fatigue syndrome).
Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with selected phosphorus nucleophiles
Adamek, Jakub,egrzyk-Schlieter, Anna W.,Ste?, Klaudia,Walczak, Krzysztof,Erfurt, Karol
, (2019/09/30)
In this study, Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with phosphites, phosphonites, and phosphinites was used in the synthesis of a wide range of phosphorus analogs of α-amino acids such as 1-imidoalkylphosphonates, 1-imidoalkylphosphinates, and 1-imidoalkylphosphine oxides. Large differences were observed in the reactivity of substrates depending on their structure, especially on the type of phosphonium moiety and N-protecting group. The conditions under which the expected products can be obtained in good to excellent yields have been developed. Mechanistic aspects of the transformation have been provided.
Oxidative Dehydroxymethylation of Alcohols to Produce Olefins
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Paragraph 0058, (2019/09/06)
Catalyst compositions for the conversion of aldehyde compounds and primary alcohol compounds to olefins are disclosed herein. Reactions include oxidative dehydroxymethylation processes and oxidative dehydroformylation methods, which are beneficially conducted in the presence of a sacrificial acceptor of H2 gas, such as N,N-dimethylacrylamide.