34892-10-9

Basic information

• Product Name: (R)-3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic acid
• Synonyms: (R)-3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic acid
• CAS NO: 34892-10-9
• Molecular Formula: C₁₁H₁₀O₅
• Molecular Weight: 222.19
• Mol File: 34892-10-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic acid(34892-10-9)
• EPA Substance Registry System: (R)-3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-carboxylic acid(34892-10-9)

Safety Data

• Hazardous Substances Data: 34892-10-9(Hazardous Substances Data)

Upstream product

• 4825-86-9 N-{[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-7-yl]-carbonyl}-L-phenylalanine 
• 141207-14-9 methyl (R)-(-)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-(1H)-2-benzopyran-7-carboxylate 

Downstream Products

• 480-33-1 (R)-(-)-mellein 

Relevant articles and documents

A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A

The hydrolyses of the ochratoxins and analogues by carboxypeptidase A were assessed. This was done by measuring the amount of phenylalanine formed with liquid chromatography coupled to tandem electrospray mass spectrometry. The kinetic data of ochratoxin A, ochratoxin B, and the synthetic bromo-ochratoxin B were compared to the values of a number of synthesized structure analogues, namely, ochratoxin A methyl ester, ochratoxin B methyl ester, N-(2-hydroxybenzoyl)phenylalanine, N-(5-chloro-2-hydroxybenzoyl)phenylalanine, N-(5-bromo-2-hydroxybenzoyl)phenylalanine, and N-(5-fluoro-2-hydroxybenzoyl)phenylalanine. The halogen-containing analogues had lower turnovers than their des-halo analogues. There are no substantial differences in the kinetic data between the different halogen-containing analogues.

Crystal Structures and Conformational Analysis of Ochratoxin A and B: Probing the Chemical Structure causing Toxicity

Studies performed on two metabolites from Aspergillus ochraceus, ochratoxin A (1) and B (2), have yielded information related to the steric, conformational, and electric considerations that could contribute to the different toxicities of these metabolites