34893-50-0 Usage
Description
2,5-Dimethylpiperidine is an organic compound with the molecular formula C7H14N. It is a heterocyclic compound featuring a six-membered nitrogen-containing ring structure, specifically a piperidine derivative with two methyl groups attached at the 2nd and 5th positions. 2,5-dimethylpiperidine is known for its potential applications in various chemical and pharmaceutical syntheses due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
2,5-Dimethylpiperidine is used as a synthetic intermediate for the production of chromen-2-ones and chromen-4-ones derivatives. These derivatives are known to be inhibitors that target DNA-PK (DNA-dependent protein kinase), an enzyme that plays a crucial role in DNA repair and is often overexpressed in various types of cancer. By inhibiting DNA-PK, these compounds can potentially disrupt the cancer cells' ability to repair their DNA, making them more susceptible to the effects of radiation and certain chemotherapy drugs.
Additionally, 2,5-dimethylpiperidine may also be utilized in the development of other pharmaceutical compounds due to its versatile chemical structure and reactivity. Its applications in the pharmaceutical industry could extend to the synthesis of various drugs targeting different therapeutic areas, such as cardiovascular, neurological, and anti-inflammatory treatments.
Used in Chemical Synthesis:
In the broader field of chemical synthesis, 2,5-dimethylpiperidine can be employed as a building block for the creation of more complex organic molecules. Its unique structure allows for various functional group transformations and reactions, making it a valuable component in the synthesis of a wide range of compounds with potential applications in different industries, such as agrochemicals, dyes, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 34893-50-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,8,9 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 34893-50:
(7*3)+(6*4)+(5*8)+(4*9)+(3*3)+(2*5)+(1*0)=140
140 % 10 = 0
So 34893-50-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H15N/c1-6-3-4-7(2)8-5-6/h6-8H,3-5H2,1-2H3
34893-50-0Relevant articles and documents
Oxidation of methylpiperidine derivatives with regard to chirality
M?hrle, Hans,Berkenkemper, Thomas
experimental part, p. 1514 - 1523 (2008/10/09)
When 2-(2-methyl-1-piperidinyl)ethanol derivatives 3a and 3b were dehydrogenated with Hg(II)-EDTA, an iminium function involving the tertiary a-carbon atom of the piperidine ring is formed regioselectively. Cyclization of these intermediates yielded diastereomeric mixtures of oxazolidines 7a and 7b, in solutions of which hydroxy-enamine species 8a/9a and 8b/9b, respectively, could be detected by NMR spectroscopy. A hydroxy-enamine derived from 7a could be trapped by cycloaddition to tetrazine 10. Protonation of the oxazolidines generated the iminium salts 6a/6b·X with loss of a chirality center. For prevention of different directions of ring dehydrogenation in the 2-(3-methyl-1-piperidinyl)ethanol compounds, the 6-position was blocked with two methyl groups. With amino alcohol 17, the isolation of one of the racemates in pure form was achieved, which by dehydrogenation produced a diastereoisomeric lactam mixture 18, as shown by NMR spectroscopy. Reaction of 2-(4-methyl-1-piperidinyl)ethanol 19 with Hg(II)-EDTA gave rise to a diastereomeric lactam mixture 21 in the ratio 60:40. From enantiomerically pure phenyloxiranes, the amino alcohols R(-)-19 and S(+)-19 became available. Their dehydrogenation under standardized conditions always showed a spreading range of isomeric lactams, which could not be separated.
