349404-17-7Relevant articles and documents
Highly efficient preparation of amides from aminium carboxylates using N-(p-toluenesulfonyl) imidazole
Behrouz, Somayeh,Rad, Mohammad Navid Soltani,Forouhari, Elham
, p. 101 - 106 (2016)
Treatment of aminium carboxylates with N-(p-toluenesulfonyl)imidazole in the presence of triethylamine in DMF at 100 °C afforded the corresponding amides in good to excellent yields. N-(p-Toluenesulfonyl)imidazole proved to be a highly efficient coupling reagent for the preparation of numerous structurally diverse primary, secondary and tertiary amides.
Zirconium catalyzed amide formation without water scavenging
Lundberg, Helena,Tinnis, Fredrik,Adolfsson, Hans
, (2019/07/31)
A scalable homogeneous metal-catalyzed protocol for direct amidation of carboxylic acids is presented. The use of 2–10?mol% of the commercially available Zr(Cp)2(OTf)2·THF results in high yields of amides at moderate temperature, using an operationally convenient reaction protocol that circumvents the use of water scavenging techniques.
N-Heterocyclic carbene-based well-defined ruthenium hydride complexes for direct amide synthesis from alcohols and amines under base-free conditions
Kim, Kunsoon,Kang, Byungjoon,Hong, Soon Hyeok
, p. 4565 - 4569 (2015/06/08)
Readily synthesized, well-defined N-heterocyclic carbene-based ruthenium(II) hydride complexes were developed for amide synthesis from alcohols and amines under base-free conditions. Diverse amides were synthesized in fair-to-excellent yields. In the case of secondary amines, where direct dehydrogenative amidation is not feasible, a catalytic amount of a base was required to promote the transamidation of esters, which are byproducts of alcohol dimerization.