349459-07-0

Basic information

• Product Name: 4'-(9-acridinylamino) methanesulfon-m-anisidine
• Synonyms: 4'-(9-acridinylamino) methanesulfon-m-anisidine
• CAS NO: 349459-07-0
• Molecular Weight: 393.466
• Mol File: 349459-07-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4'-(9-acridinylamino) methanesulfon-m-anisidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(9-acridinylamino) methanesulfon-m-anisidine(349459-07-0)
• EPA Substance Registry System: 4'-(9-acridinylamino) methanesulfon-m-anisidine(349459-07-0)

Safety Data

• Hazardous Substances Data: 349459-07-0(Hazardous Substances Data)

Upstream product

• 132445-56-8 N-(2-methoxy-4-nitrophenyl)acridin-9-amine 
• 1207-69-8 9-Chloroacridine 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 124-63-0 methanesulfonyl chloride 
• 74-93-1 methylthiol 
• 117252-49-0 N(1')-(methylsulfonyl)-N(4')-(9-acridynyl)-3'-methoxy-2',5'-cyclohexadiene-1',4'-diimine 
• 57165-06-7 N-(4-amino-3-methoxyphenyl)methanesulfonamide 

Downstream Products

• 57165-06-7 N-(4-amino-3-methoxyphenyl)methanesulfonamide 
• 77273-65-5 4-[2-(Acridin-9-ylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid 
• 87764-57-6 N-[4-[(E)-Acridin-9-ylimino]-3-methoxy-cyclohexa-2,5-dien-(E)-ylidene]-methanesulfonamide 

Relevant articles and documents

With tumor-responsive release drug compound or its pharmaceutically acceptable salts and its preparation, application

The invention discloses a compound with a tumor responsive drug release function, or a pharmaceutical salt of the compound, as well as preparation and application of the compound, and belongs to the technical field of drug targeting release. The structural formula of the compound is as shown in the Specifications. The designed and synthesized novel tumor cell-sensitive compound disclosed by the invention can stably exist in the normal physiological environment, can release amsacrine drug when entering into tumor cells and performing a cascade reaction under a high-concentration glutathione environment in the tumor cells, and can be used for prepare a novel targeting antitumor drug. In addition, the preparation method of the compound disclosed by the invention is simple and convenient to operate, moderate in conditions, and high in reaction yield.

Reactivity of Quinone Imine and Quinone Diimine Metabolites of the Antitumor Drug Amsacrine and Related Compounds to Nucleophiles

The quinone diimine AQDI (7) and the quinone imine AQI (10) (products of oxidative metabolism of the clinical antileukemia drug amsacrine (1)) and related compounds were prepared, and their reactions with a variety of nucleophiles were studied.Reaction of

Multi-step process for the production of methanesulfon-m-anisidide, 4'-(9-acridinylamino)-

A multi-step method of producing the compound methanesulfon-m-anisidide, 4''-(9-acridinylamino)-, acetate (VII), which may be in free base form and designated NSC 249992, also known as AMSA. This compound is produced by an elegant process from a starting material, 4-butyrylamino-3-methoxy-nitrobenzene, which is later transformed to methanesulfon-m-anisidide, 4''-amino- (IV) and is coupled or joined to 9-chloro-acridine, producing the chloride salt which is later converted to the acetate.