350-29-8 Usage
Description
3-Fluoro-4-hydroxybenzoic acid is a halo-substituted 4-hydroxybenzoic acid derivative, characterized by the presence of a fluorine atom at the 3rd position and a hydroxyl group at the 4th position of the benzene ring. It can be synthesized from 3-fluoro-4-methoxybenzoic acid through a demethylation process and is known for its yellow solid appearance.
Uses
Used in Pharmaceutical Industry:
3-Fluoro-4-hydroxybenzoic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential applications in treating different medical conditions.
Used in Synthesis of Specific Compounds:
3-Fluoro-4-hydroxybenzoic acid is used as a starting material for the preparation of (S)-2-methylbutyl-3-fluoro-4-hydroxy benzoate and 4-n-alkoxy-3-fluorobenzoic acids. These compounds have specific applications in various fields, such as pharmaceuticals or chemical research.
Used in Synthesis of Potent Inhibitors:
3-Fluoro-4-hydroxybenzoic acid is also utilized in the synthesis of bis 3-fluoro-4-hydroxybenzoates, which are potent KCa2/3 pan-inhibitors. These inhibitors play a crucial role in regulating ion channels, which can have significant implications in the treatment of various diseases and conditions related to ion channel dysfunction.
Check Digit Verification of cas no
The CAS Registry Mumber 350-29-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 350-29:
(5*3)+(4*5)+(3*0)+(2*2)+(1*9)=48
48 % 10 = 8
So 350-29-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H5FO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9H,(H,10,11)/p-1
350-29-8Relevant articles and documents
Preparation of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate
Li, Jianqing,Smith, Daniel,Qiao, Jennifer X.,Huang, Stella,Krishnananthan, Subramaniam,Wong, Henry S.,Salvati, Mark E.,Balasubramanian, Balu N.,Chen, Bang-Chi
scheme or table, p. 633 - 637 (2009/07/01)
An efficient synthesis of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate in moderate to excellent yields is described. High regioselectivity was observed in some cases. Georg Thieme Verlag Stuttgart.
Influence of fluoro substituents on the mesophase behaviour of banana-shaped molecules
Bedel,Rouillon,Marcerou,Laguerre,Nguyen,Achard
, p. 2214 - 2220 (2007/10/03)
Three new series of bent-shaped five-ring liquid crystals, based on the ester of isophthalic acid as the central core and azomethine linkages, are presented. They differ by the number and the position of halogeno substituents on the outer rings. This lateral substitution strongly influences the type of mesophases formed. Calculations were performed to determine the modification of the distribution of charge along the different molecules.
Synthesis of 3-deoxy-3,3-difluoroshikimic acid and its 4-epimer from quinic acid
Jiang, Shende,Singh, Gurdial,Boam, Deborah J.,Coggins, John R.
, p. 4087 - 4090 (2007/10/03)
3-Deoxy-3,3-difluoroshikimic acid 2 and its 4-epimer 3 as new analogues of shikimic acid have been synthesised from quinic acid in overall yields of 30% and 12%, respectively.
