350015-18-8

Basic information

• Product Name: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-
• CAS NO: 350015-18-8
• Molecular Formula: C16H9NO
• Molecular Weight: 231.254
• Mol File: 350015-18-8.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-(350015-18-8)
• EPA Substance Registry System: Benzonitrile, 4-(3-oxo-3-phenyl-1-propynyl)-(350015-18-8)

Safety Data

• Hazardous Substances Data: 350015-18-8(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 3032-92-6 4-cyanophenylacetylene 
• 59-88-1 phenylhydrazine hydrochloride 
• 134-81-6 benzil 
• 6125-26-4 phenyl(2-phenyl-2,3-dihydrobenzo[d]thiazol-2-yl)methanone 
• 3058-39-7 4-iodobenzonitrile 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 926013-72-1 4-(3-hydroxy-3-phenylprop-1-yn-1-yl)benzonitrile 
• 100-52-7 benzaldehyde 
• 64-18-6 formic acid 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 62-53-3 aniline 
• 98-88-4 benzoyl chloride 
• 75867-40-2 4-[2-(trimethylsilyl)ethynyl]benzonitrile 

Downstream Products

• 1198463-89-6 (Z)-3-(4-cyanophenyl)-1-phenyl-3-(phenylamino)prop-2-en-1-one 
• 920145-51-3 4-(5-methylbenzo[d]oxazol-2-yl)benzonitrile 
• 29822-79-5 4-(2-phenylethynyl)benzonitrile 
• 1179538-75-0 C₂₂H₁₄ClIN₂O 
• 72758-75-9 (E)-4-(3-oxo-3-phenylprop-1-en-1-yl)benzonitrile 
• 36803-56-2 4-(2-(4-methoxyphenyl)-2-oxoacetyl)benzonitrile 

Relevant articles and documents

Electrochemical Palladium-Catalyzed Oxidative Sonogashira Carbonylation of Arylhydrazines and Alkynes to Ynones

Oxidative carbonylation using carbon monoxide has evolved as an attractive tool to valuable carbonyl-containing compounds, while mixing CO with a stoichiometric amount of a chemical oxidant especially oxygen is hazardous and limits its application in scale-up synthesis. By employing anodic oxidation, we developed an electrochemical palladium-catalyzed oxidative carbonylation of arylhydrazines with alkynes, which is regarded as an alternative supplement of the carbonylative Sonogashira reaction. Combining an undivided cell with constant current mode, oxygen-free conditions avoids the explosion hazard of CO. A diversity of ynones are efficiently obtained using accessible arylhydrazines and alkynes under copper-free conditions. A possible mechanism of the electrochemical Pd(0)/Pd(II) cycle is rationalized based upon cyclic voltammetry, kinetic studies, and intermediates experiments.

Sc(OTf)3-catalyzed [3 + 2]-cycloaddition of nitrones with ynones

An efficient approach to access functionalized (2,3-dihydroisoxazol-4-yl) ketones has been developed by reacting nitrones 4 with ynones 7 or terminal ynones 10 in a one-pot fashion. The reaction went through a formal Sc(OTf)3-catalyzed [3 + 2]-cycloaddition process to generate a number of functionalized (2,3-dihydroisoxazol-4-yl) ketones 11aa-11aw, 11ba-11la and 12aa-12ae in moderate to good yields. This journal is

Gold-catalyzed partial hydrogenation of activated alkynes mediated by triphenylphosphine

Gold(I) can exhibit a cooperative effect with triphenylphosphine, accelerating the triphenylphosphine-mediated partial hydrogenation of activated alkynes. In this protocol, 3-arylpropiolates are selectively reduced to the Z -isomer when the aryl ring bears an electron-donor substituent, whereas 3-arylpropynones are reduced to the E-isomers.