35015-91-9Relevant articles and documents
Applications of ethyl carboethoxyformimidate to heterocyclic synthesis: Preparation of condensed pyrazinones and 1,4-oxazinones
McKillop, Alexander,Chattopadhyay, Shital K.,Henderson, Alan,Avendano, Carmen
, p. 301 - 304 (1997)
Aromatic and heteroaromatic 1,2-diamines, and o-aminophenols, condense smoothly with ethyl carboethoxyformimidate to give good yields of condensed pyrazinones and 1,4-oxazinones.
Direct C(sp2)?H Amination to Synthesize Primary 3-aminoquinoxalin-2(1H)-ones under Simple and Mild Conditions
Yang, Qiming,Yang, Zibing,Tan, Yushi,Zhao, Jiquan,Sun, Qian,Zhang, Hong-Yu,Zhang, Yuecheng
supporting information, p. 1662 - 1667 (2019/02/19)
A convenient C?H amination of quinoxalin-2-ones has been developed. This transformation provides concise access to 3-aminoquinoxalin-2(1H)-ones with a broad tolerance of functional groups, utilizing TMSN3 as an amino source under simple and mild conditions. The target 3-aminoquinoxalin-2(1H)-ones are important intermediates for the synthesis of biologically active 3-N-substituted quinoxalin-2-one derivatives. (Figure presented.).
Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives
Galal, Shadia A.,Abdelsamie, Ahmed S.,Tokuda, Harukuni,Suzuki, Nobutaka,Lida, Akira,Elhefnawi, Mahmoud M.,Ramadan, Raghda A.,Atta, Mona H.E.,El Diwani, Hoda I.
experimental part, p. 327 - 340 (2011/02/25)
The reaction of o-phenylene diamine and ethyl oxamate is reinvestigated and led to 3-aminoquinoxalin-2(1H)-one rather than benzimidazole-2-carboxamide as was previously reported. The structure of the obtained quinoxaline has been confirmed by X-ray. The anti-tumor activity of synthesized quinoxalines 1-21 has been evaluated by studying their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13- acetate (TPA). Among the studied compounds 1-21, compounds 12, 8, 13, 18, 17 and 19, respectively, demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity and their effects being stronger than that of a representative control, oleanolic acid. Furthermore, compound 12 exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. The result of the present investigation indicated that compound 12 might be valuable as a potent cancer chemopreventive agent. Moreover, the molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors.