35022-79-8

Basic information

• Product Name: 1-(6-Phenylpyridin-3-yl)ethanone
• Synonyms: 1-(6-Phenylpyridin-3-yl)ethanone;3-Acetyl-6-phenylpyridine, 97%
• CAS NO: 35022-79-8
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.23254
• Mol File: 35022-79-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(6-Phenylpyridin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-Phenylpyridin-3-yl)ethanone(35022-79-8)
• EPA Substance Registry System: 1-(6-Phenylpyridin-3-yl)ethanone(35022-79-8)

Safety Data

• Hazardous Substances Data: 35022-79-8(Hazardous Substances Data)

Usage

Description

1-(6-Phenylpyridin-3-yl)ethanone, also known as 3-Acetyl-6-phenylpyridine, is an organic compound with the molecular formula C15H13NO. It belongs to the class of ketones, characterized by the presence of a carbonyl group (C=O) bonded to two carbon atoms. 1-(6-Phenylpyridin-3-yl)ethanone features a pyridine ring and a phenyl group attached to the carbon atom in the ketone group, which contributes to its unique properties and potential applications.

Uses

Used in Pharmaceutical Industry:
1-(6-Phenylpyridin-3-yl)ethanone is used as an intermediate in the synthesis of various pharmaceuticals for [application reason]. Its unique chemical structure allows it to serve as a building block for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(6-Phenylpyridin-3-yl)ethanone is used as an intermediate for the synthesis of various agrochemicals for [application reason]. Its chemical properties make it a valuable component in the creation of compounds that can be used in the agricultural sector for pest control, crop protection, and other related applications.
Used in Research and Development:
1-(6-Phenylpyridin-3-yl)ethanone also has potential applications in research and development for [application reason]. Its distinctive chemical structure and properties make it an interesting candidate for further exploration and experimentation in various scientific fields, potentially leading to the discovery of new compounds and applications.

Upstream product

• 917-54-4 methyllithium 
• 1228932-08-8 (E)-3-(azidomethyl)-6-phenylhex-3-en-5-yn-2-one 
• 350-03-8 methyl-3-pyridylketone 
• 98-80-6 phenylboronic acid 
• 139042-59-4 1-(6-bromopyridin-3-yl)ethanone 
• 87673-10-7 1-Ethoxycarbonyl-3-trimethylsilanyl-pyridinium; chloride 
• 87673-11-8 2-Phenyl-5-trimethylsilanyl-2H-pyridine-1-carboxylic acid ethyl ester 
• 59020-10-9 3-(tributylstannyl)pyridine 
• 87673-12-9 5-Acetyl-2-phenyl-2H-pyridine-1-carboxylic acid ethyl ester 
• 110601-10-0 5-acetyl-1-(phenoxycarbonyl)-2-phenyl-1,2-dihydropyridine 
• 591-50-4 iodobenzene 
• 138823-76-4 3-Acetyl-1-ethoxycarbonyl-pyridinium; chloride 

Downstream Products

• 1048004-06-3 3-dimethylamino-1-(6-phenylpyridin-3-yl)prop-2-en-1-one 
• 1613027-82-9 tert-butyl [2-(5-acetylpyridin-2-yl)phenyl]carbamate 
• 1569902-04-0 6-ethyl-5-[3-(6-phenyl-pyridin-3-yl)-but-1-ynyl]-pyrimidine-2,4-diamine 
• 1379667-33-0 N-[2-(5-acetylpyridin-2-yl)phenyl]-4-methylbenzenesulfonamide 
• 1234327-08-2 3-(dimethylamino)-1-(6-phenylpyridin-3-yl)prop-2-en-1-one 

Relevant articles and documents

Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19

The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. Herein, we report the discovery of 9,10-dihydrophenanthrene derivatives as non-peptidomimetic and non-covalent inhibitors of the SARS-CoV-2 3CLpro. The structure-activity relationships of 9,10-dihydrophenanthrenes as SARS-CoV-2 3CLpro inhibitors have carefully been investigated and discussed in this study. Among all tested 9,10-dihydrophenanthrene derivatives, C1 and C2 display the most potent SARS-CoV-2 3CLpro inhibition activity, with IC50 values of 1.55 ± 0.21 μM and 1.81 ± 0.17 μM, respectively. Further enzyme kinetics assays show that these two compounds dose-dependently inhibit SARS-CoV-2 3CLpro via a mixed-inhibition manner. Molecular docking simulations reveal the binding modes of C1 in the dimer interface and substrate-binding pocket of the target. In addition, C1 shows outstanding metabolic stability in the gastrointestinal tract, human plasma, and human liver microsome, suggesting that this agent has the potential to be developed as an orally administrated SARS-CoV-2 3CLpro inhibitor.

Ruthenium-catalysedmeta-selective CAr-H bond alkylationviaa deaminative strategy

The use of aliphatic amines as alkylating reagents in organic synthesisviaC-N bond activation remains underdeveloped. We herein describe a novel ruthenium-catalysed and directing-group assisted protocol for the synthesis ofmeta-alkylated arenesviadual C-H and C-N activation. Bench-stable and easily handled redox-active Katritzky pyridinium salts derived from abundant amines and amino acid species were used as alkyl radical precursors. This catalytic reaction could accommodate a broad range of functional groups and provide access to variousmeta-alkylated products.

Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase

Compounds of Formula I and Formula IA are inhibitors of dihydrofolate reductase and are suitable for use in compositions and methods for dihydrofolate reductase inhibition or, more specifically, treatment of a fungal infection, a bacterial infection or a protozoal infection, and, in specific embodiments, treatment of a fungal infection caused by C. albicans or C. glabrata: wherein R, R1, R2, R3, R4, A, B, E, V, W, X, Y and Z are as defined herein.