35030-49-0

Basic information

• Product Name: Benzenepropanoic acid, a-phenyl-, methyl ester
• CAS NO: 35030-49-0
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Mol File: 35030-49-0.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-phenyl-, methyl ester(35030-49-0)
• EPA Substance Registry System: Benzenepropanoic acid, a-phenyl-, methyl ester(35030-49-0)

Safety Data

• Hazardous Substances Data: 35030-49-0(Hazardous Substances Data)

Upstream product

• 13049-41-7 1,1-dimethoxy-2-phenylethene 
• 100-39-0 benzyl bromide 
• 67-56-1 methanol 
• 4980-70-5 1,3-diphenyl-1-propyne 
• 36854-27-0 2,3-diphenylacrylic acid methyl ester 
• 41366-89-6 methyl 2-acetoxy-2,3-diphenylpropionate 
• 102-04-5 1,3-Diphenylpropanone 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 140-29-4 phenylacetonitrile 
• 186581-53-3 diazomethane 
• 10465-70-0 (2E)-2-(4-chlorophenyl)-3-phenylprop-2-enoic acid 
• 728-04-1 trans-α-(2'-chlorophenyl)cinnamic acid 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 98-80-6 phenylboronic acid 

Downstream Products

• 57015-18-6 1-(1-benzyl-2-methyl-1-propenyl)benzene 
• 922501-75-5 N-methoxy-N-methyl-2,3-diphenyl-propionamide 
• 440676-17-5 2,3-Diphenylpropionic Acid (3R)-1-azabicyclo[2.2.2]oct-3-yl Ester 
• 886586-69-2 2-fluoro-2,3-diphenylpropanoic acid 
• 1216634-44-4 C₂₁H₂₆N₂O 
• 1413940-38-1 C₂₀H₂₃FN₂O 
• 17841-39-3 2-Fluor-2,3-diphenyl-propionsaeure-methylester 
• 57625-75-9 methyl 2,3-diphenyl-2-methylpropionate 
• 94942-89-9 2,3-diphenylpropanoic acid 
• 36854-27-0 methyl (E)-2,3-diphenyl-2-propenoate 
• 7511-43-5 2,3-diphenyl-2-methylpropionic acid 
• 127867-80-5 2-benzyl-2-phenylpropanoyl chloride 
• 133043-95-5 1,1'-(3-chloro-1,2-propanediyl)dibenzene 
• 3536-29-6 2,3-diphenyl-1-propanol 

Relevant articles and documents

On the mechanism of conversion of 4-carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to indeno[1,2-c]isoquinolines by thionyl chloride

It has been known for a long time that thionyl chloride can effectively mediate the transformation of 4-carboxy-3,4-dihydro-3-phenyl-1(2H)-isoquinolones to indeno[1,2-c]isoquinolines. The mechanism of this unique transformation, however, remains to be established. Evidence is presented to demonstrate that (1) the two-electron dehydrogenation precedes Friedel-Crafts cyclization and (2) the two-electron dehydrogenation occurs via H-4 deprotonation and subsequent O-sulfinylation of the lactam moiety instead of C-sulfinylation of the carbon α to the carboxyl group.

Transition-metal-free and base promoted C-C bond formationviaC-N bond cleavage of organoammonium salts

A transition-metal-free and base promoted C-C bond forming reaction of benzyl C(sp3)-H bond with organoammonium saltsviaC-N bond cleavage has been reported. Benzyl ammonium salts as well as cinnamyl ammonium salt could couple readily with various benzyl C(sp3)-H species, producing the corresponding products in moderate to excellent yields with good functional group tolerance. Late stage chemical manipulation enabled the specific 1,2-diarylethane structure of products transformed into useful olefin compoundsviadehydrogenation, which further demonstrated the utility of this reaction.

Formation of quaternary carbons through cobalt-catalyzed C(sp3)-C(sp3) Negishi cross-coupling

Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp3)-C(sp3) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl groups to halo-carbonyl substrates. The cross-coupling reaction is selective for C(sp3)-over C(sp2)-halides, in contrast to most used catalytic metals, and allows access to novel scaffolds of pharmaceutical interest. NMR mechanistic studies suggest the presence of Co(0) complexes as catalytic species. This journal is