35038-32-5 Usage
Description
Methyl (2S-trans)-13-ethyl-2,3-dihydro-18-(methoxycarbonyl)-20-(2-methoxy-2-oxoethyl)-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionate is a complex organic compound with a porphyrin structure. It is characterized by its unique molecular arrangement and functional groups, which may have potential applications in various fields due to its chemical properties.
Uses
1. Used in Photodynamic Therapy (PDT):
Methyl (2S-trans)-13-ethyl-2,3-dihydro-18-(methoxycarbonyl)-20-(2-methoxy-2-oxoethyl)-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionate is used as an amphiphilic photosensitizer for photodynamic therapy. Its molecular structure allows it to absorb light and generate reactive oxygen species, which can be effective in targeting and destroying cancer cells upon light activation.
2. Used in Drug Delivery Systems:
In the pharmaceutical industry, methyl (2S-trans)-13-ethyl-2,3-dihydro-18-(methoxycarbonyl)-20-(2-methoxy-2-oxoethyl)-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionate can be utilized as a component in the development of drug delivery systems. Its amphiphilic nature may facilitate the encapsulation and targeted delivery of therapeutic agents, potentially improving their bioavailability and reducing side effects.
3. Used in Chemical Research:
Due to its complex structure and unique properties, methyl (2S-trans)-13-ethyl-2,3-dihydro-18-(methoxycarbonyl)-20-(2-methoxy-2-oxoethyl)-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionate may also be used as a research tool in chemical and materials science. It can be employed to study various phenomena, such as molecular interactions, self-assembly processes, and the development of novel materials with specific properties.
4. Used in Analytical Chemistry:
methyl (2S-trans)-13-ethyl-2,3-dihydro-18-(methoxycarbonyl)-20-(2-methoxy-2-oxoethyl)-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionate's optical and electronic properties may make it a valuable tool in analytical chemistry for the detection and quantification of various substances. It could potentially be used as a probe or a sensing element in the development of new analytical methods and techniques.
5. Used in Material Science:
Methyl (2S-trans)-13-ethyl-2,3-dihydro-18-(methoxycarbonyl)-20-(2-methoxy-2-oxoethyl)-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionate may also find applications in material science, particularly in the development of new materials with specific optical, electronic, or catalytic properties. Its unique structure could be exploited to create materials with enhanced performance in various applications, such as solar energy conversion, sensors, or catalysts.
Check Digit Verification of cas no
The CAS Registry Mumber 35038-32-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,0,3 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 35038-32:
(7*3)+(6*5)+(5*0)+(4*3)+(3*8)+(2*3)+(1*2)=95
95 % 10 = 5
So 35038-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C37H40N4O6/c1-10-22-18(3)26-15-28-20(5)24(12-13-32(42)45-7)35(40-28)25(14-33(43)46-8)36-34(37(44)47-9)21(6)29(41-36)17-31-23(11-2)19(4)27(39-31)16-30(22)38-26/h10,15-17,20,24H,1,11-14H2,2-9H3/b26-15-,27-16-,28-15u,29-17-,30-16u,31-17u,35-25-,36-25u/t20-,24-/m0/s1
35038-32-5Relevant articles and documents
Synthesis and: In vitro phototoxicity of novel π-extension derivatives of chlorin e6
Cao, Lei,Guo, Xiuhan,Wang, Liu,Wang, Shisheng,Li, Yueqing,Zhao, Weijie
, p. 14279 - 14287 (2017)
Six novel E-32-aryl substituted chlorins (5a-5f) were synthesized via improved regioselective bromination and Suzuki-Miyaura cross-coupling reactions with chlorin e6 (1) as a starting material. All the π-extension photosensitizers 5a-5f exhibited significant bathochromic-shifts (ca. 10 nm) in the far red part of the spectrum called the phototherapeutic window and decreased photobleaching under irradiation of 660 nm light. Moreover, 5a-5f possessed higher phototoxicity in vitro against HepG2 cells (IC50 = 0.73 ± 0.04, 2.33 ± 0.22, 0.78 ± 0.05, 0.50 ± 0.04, 2.25 ± 0.16 and 0.65 ± 0.11 μM, respectively) compared with chlorin e6 (IC50 = 28.9 ± 1.2 μM). The enhanced cellular uptake and reactive oxygen species (ROS) production of modified chlorins were found to be responsible for their increased in vitro phototoxicity.
Chlorin derivative, corresponding preparation method and application thereof
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Paragraph 0255-0259, (2020/11/25)
The invention relates to a chlorin derivative, a preparation method of the chlorin derivative, a photoacoustic sensitive agent containing the chlorin derivative, an antitumor drug containing the chlorin derivative, and application of the chlorin derivative in preparation of the antitumor drug. The chlorin derivative of the present invention can be used for photodynamic therapy and sonodynamic therapy so as to effectively suppress and treat cancer.
Functionalization of chlorin e6 trimethylester towards potential amphiphilic photosensitizers for photodynamic therapy
Bauer, Daniela,Nghiem, Hai Vu,Tien, Doan Duy,Stelten, Johannes,Montforts, Franz-Peter
, p. 243 - 250 (2019/02/19)
Chlorins (dihydroporphyrins) are considered, due to their ideal photophysical properties, as attractive photosensitizers for photodynamic therapy (PDT) of cancer and other therapeutic and diagnostic applications. Chlorophyll a, as a naturally occurring chlorin, forms an almost unlimited renewable resource for preparation of potential biologically active chlorin photosensitizers and fluorescence markers. To achieve amphiphilic photosensitizers which might be selectively enriched in tumor cells, we addressed linkage of per se lipophilic chlorophyll derivatives with carbohydrate based hydrophilic aminopolyols.
