350672-16-1

Basic information

• Product Name: 2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole(SALTDATA: FREE)
• Synonyms: 2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole(SALTDATA: FREE)
• CAS NO: 350672-16-1
• Molecular Formula: C₉H₆ClFN₂O
• Molecular Weight: 212.6081432
• Mol File: 350672-16-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 321.8±52.0 °C(Predicted)
• Appearance: /
• Density: 1.364±0.06 g/cm3(Predicted)
• PKA: -6.11±0.44(Predicted)
• CAS DataBase Reference: 2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole(SALTDATA: FREE)(350672-16-1)
• EPA Substance Registry System: 2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole(SALTDATA: FREE)(350672-16-1)

Safety Data

• Hazardous Substances Data: 350672-16-1(Hazardous Substances Data)

Usage

General Description

2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole is a chemical compound with the molecular formula C9H6ClFN2O. It is an oxadiazole derivative used in medicinal chemistry and pharmaceutical research as a potential drug candidate. 2-(chloromethyl)-5-(3-fluorophenyl)-1,3,4-oxadiazole(SALTDATA: FREE) has a chloromethyl group and a fluorophenyl group attached to the oxadiazole ring, which may contribute to its biological activity. It is important to handle this chemical with care and follow safety protocols when using it in laboratory settings.

Upstream product

• 455-68-5 methyl 3-fluorobenzoate 
• 455-38-9 3-fluorobenzoic acid 
• 451-02-5 ethyl 3-fluorobenzoate 
• 499-55-8 3-fluoro-benzoic acid hydrazide 
• 74974-54-2 2-chloro-1,1,1-trimethoxyethane 
• 905118-28-7 3-fluoro-benzoic acid N'-chloroacetyl-hydrazide 

Relevant articles and documents

Oxazole ring-containing honokiol thioether derivative and preparation method and application thereof

The invention discloses an oxazole ring-containing honokiol thioether derivative, a preparation method thereof and application of the oxazole ring-containing honokiol thioether derivative as an alpha-glucosidase inhibitor, the chemical structure of the oxazole ring-containing honokiol thioether derivative is shown as a general formula (I), and R is selected from non-substituted or substituted phenyl. Compared with the prior art, the invention provides the novel honokiol thioether derivative containing the oxazole ring, and the honokiol thioether derivative containing the oxazole ring has good inhibitory activity on alpha-glucosidase, provides more possibilities for treating diabetes, and is expected to be used for preparing novel candidate drug molecules for treating diabetes. In addition, the preparation process is simple, the cost is low, and the yield is high.

Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents

Twenty benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety were synthesized and evaluated for their anti-oxidant and anti-inflammatory activities. Among these compounds, 8h and 8l were appeared to have high radical scavenging efficacies as 0.05 ± 0.02 and 0.07 ± 0.03 mmol/L of IC50 values in ABTS+[rad] bioassay, respectively. In anti-inflammatory tests, compound 8h displayed good activity with 57.35% inhibition after intraperitoneal administration, which was more potent than the reference drug (indomethacin). Molecular modeling studies were performed to investigate the binding mode of the representative compound 8h into COX-2 enzyme. In vitro enzyme study implied that compound 8h exerted its anti-inflammatory activity through COX-2 inhibition.

Microwave-assisted one-step synthesis of substituted 2-chloromethyl-1,3,4- oxadiazoles

We have developed a simple one-step synthesis of 2-chloromethyl-1,3,4- oxadiazoles from commercially available acylhydrazides using 1-chloro-2,2,2-trimethoxyethane as a solvent under microwave irradiation.