3507-28-6

Basic information

• Product Name: Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI)
• Synonyms: Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI);2-Chloro-5-methoxybenzothiazole;2-chloro-5-methoxybenzo[d]thiazole
• CAS NO: 3507-28-6
• Molecular Formula: C8H6ClNOS
• Molecular Weight: 199.66
• Product Categories: BENZOTHIAZOLE
• Mol File: 3507-28-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 293.5 °C at 760 mmHg
• Flash Point: 131.3 °C
• Appearance: /
• Density: 1.404 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.37±0.10(Predicted)
• CAS DataBase Reference: Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI)(3507-28-6)
• EPA Substance Registry System: Benzothiazole, 2-chloro-5-methoxy- (6CI,7CI,8CI,9CI)(3507-28-6)

Safety Data

• Hazardous Substances Data: 3507-28-6(Hazardous Substances Data)

Usage

General Description

2-chloro-5-methoxy-Benzothiazole (6CI,7CI,8CI,9CI) is a chemical compound that belongs to the group of organic substances known as benzothiazoles. These are aromatic heterocyclic compounds featuring a benzene ring fused to a thiazole ring. The specific structure of 2-chloro-5-methoxy-Benzothiazole includes chlorine and methoxy substituents at the 2nd and 5th positions of the benzothiazole ring respectively. It's utilized in several chemical reactions and plays a role in the field of organic synthesis. Like other benzothiazoles, it's expected to exhibit certain biological activities, but specific details regarding its properties and applications have not been extensively researched or reported.

Upstream product

• 55690-60-3 5-methoxybenzo[d]thiazole-2(3H)-thione 
• 55690-60-3 5-methoxybenzo[d]thiazole-2-thiol 

Downstream Products

• 1207869-71-3 (5-mehoxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 1207869-02-0 (5-hydroxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 1207869-03-1 (4-bromo-5-hydroxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 1207869-49-5 (4,6-dibromo-5-hydroxybenzo[d]thiazol-2-yl)(4-phenoxyphenyl)methanone 
• 80945-74-0 2-hydrazinyl-5-methoxybenzo[d]thiazole 

Relevant articles and documents

Synthesis of novel benzo-fused heteroaryl derivatives as Ca 2+/calmodulin-dependent protein kinase II inhibitors

Based on the structure activity relationship of 2-(4-phenoxybenzoyl)-5- hydroxyindole (1), a novel structural class of Ca2+ /calmodulin-dependent protein kinase II (CaMKII) inhibitors were synthesized. We show in this study that the acidic prot

A mild and efficient one-pot synthesis of 2-aminated benzoxazoles and benzothiazoles

Previous syntheses of the biologically active 2-aminated benzoxazoles have relied on forcing thermal conditions to generate the products directly from the corresponding thiols. The resulting yields have ranged from moderate to poor. A mild and high-yielding alternative one-pot chlorination-amination procedure is described. Compounds with a variety of substitution patterns are reported and the methodology has been successfully extended to benzothiazoles. Palladium catalysis on suitably activated examples has been employed to generate the desired compounds of interest.