35077-41-9

Basic information

• Product Name: Acetamide, 2-chloro-N-(2-oxocyclohexyl)-
• CAS NO: 35077-41-9
• Molecular Formula: C8H12ClNO2
• Molecular Weight: 189.642
• Mol File: 35077-41-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, 2-chloro-N-(2-oxocyclohexyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2-chloro-N-(2-oxocyclohexyl)-(35077-41-9)
• EPA Substance Registry System: Acetamide, 2-chloro-N-(2-oxocyclohexyl)-(35077-41-9)

Safety Data

• Hazardous Substances Data: 35077-41-9(Hazardous Substances Data)

Upstream product

• 6946-05-0 2-aminocyclohexanone hydrochloride 
• 79-04-9 chloroacetyl chloride 
• 35070-77-0 N-chloro-alpha-chloroacetamide 
• 78174-28-4 2-Chloro-N-(2,2-dimethoxy-cyclohexyl)-acetamide 
• 931-57-7 1-methoxy-cyclohex-1-ene 

Downstream Products

• 143707-81-7 5-Ethyl-6-methyl-3-[(4,5,6,7-tetrahydro-benzooxazol-2-ylmethyl)-amino]-1H-pyridin-2-one 

Relevant articles and documents

Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1H)-one

A series of nonnulceoside 3-aminopyridin-2(1H)-one derivatives was synthesized and evaluated for HIV-1 RT inhibitory properties.Several analogs proved to be potent and highly selective antagonists with in vitro IC50 values as low as 19 nM in the enzyme assay using rC*dG as template*primer.Two compounds from this series, 3-amino>-5-ethyl-6-methylpyridin-2(1H)-one (34, L-697,639) and the corresponding 4,7-dichloro analogue (37, L-697,661) inhibited the spread of HIV-1 IIIb infection by 95percent in MT4 cell culture at concentrations of 25-50 nM and were selected for clinical trials as antiviral agents.