350992-10-8

Basic information

• Product Name: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one
• Synonyms: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one;Bifeprunox;7-(4-([1,1,-biphenyl]-3-ylmethyl)piperazin-1-yl)benzo[d]oxazol-2(3H)-one
• CAS NO: 350992-10-8
• Molecular Formula: C₂₄H₂₃N₃O₂
• Molecular Weight: 385.46
• Mol File: 350992-10-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.247 g/cm³
• Refractive Index: 1.643
• CAS DataBase Reference: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one(350992-10-8)
• EPA Substance Registry System: 7-[4-[(3-phenylphenyl)methyl]piperazin-1-yl]-3H-benzooxazol-2-one(350992-10-8)

Safety Data

• Hazardous Substances Data: 350992-10-8(Hazardous Substances Data)

Usage

Uses

Acute schizophrenia.

InChI:InChI=1/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)

Upstream product

• 14704-31-5 3-(bromomethyl)-1,1'-biphenyl 
• 3132-99-8 m-bromobenzoic aldehyde 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1204-60-0 biphenyl-3-carbaldehyde 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities

This paper describes the syntheses of several 1-aryl-4-(biarylmethylene)piperazines and the results of the determination of their affinity for D2 and 5-HT1A receptors. A selection of these compounds was evaluated in vivo, resulting in the identification of a drug candidate which is being clinically evaluated as a potential atypical antipsychotic with reduced extrapyrimidal side effects.

3H-BENZOOXAZOL-2-ONE MODULATORS OF D2 RECEPTOR AND/OR 5-HT1A RECEPTOR

The present invention relates to new 3H-benzooxazol-2-one modulators of D2 receptors and/or 5-HT1A receptors, pharmaceutical compositions thereof, and methods of use thereof.