351003-36-6 Usage
Description
2-Fluoro-5-iodobenzonitrile is a halogenated benzonitrile, characterized by its off-white or light brown solid appearance. It is a chemical compound that plays a significant role in the synthesis of various organic molecules, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Synthesis:
2-Fluoro-5-iodobenzonitrile is used as a key intermediate for the chemical synthesis of 4-phenoxybenzamide adenine dinucleotide. It contributes to the formation of 4-phenoxy benzamide riboside, which is an essential step in the production of this pharmaceutical compound.
Additionally, 2-Fluoro-5-iodobenzonitrile is utilized in the synthesis of 5-substituted-3-amino indazoles and 5-iodo-1-methyl-1H-indazol-3-amine. These compounds have potential applications in the development of new drugs and therapeutic agents, further highlighting the importance of 2-Fluoro-5-iodobenzonitrile in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 351003-36-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,0,0 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 351003-36:
(8*3)+(7*5)+(6*1)+(5*0)+(4*0)+(3*3)+(2*3)+(1*6)=86
86 % 10 = 6
So 351003-36-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H3FIN/c8-7-2-1-6(9)3-5(7)4-10/h1-3H
351003-36-6Relevant articles and documents
Mechanism of Cu-catalyzed aryl boronic acid halodeboronation using electrophilic halogen: Development of a base-catalyzed iododeboronation for radiolabeling applications
Molloy, John J.,O'rourke, Kerry M.,Frias, Carolina P.,Sloan, Nikki L.,West, Matthew J.,Pimlott, Sally L.,Sutherland, Andrew,Watson, Allan J. B.
supporting information, p. 2488 - 2492 (2019/04/10)
An investigation into the mechanism of Cu-catalyzed aryl boronic acid halodeboronation using electrophilic halogen reagents is reported. Evidence is provided to show that this takes place via a boronate-driven ipso-substitution pathway and that Cu is not required for these processes to operate: General Lewis base catalysis is operational. This in turn allows the rational development of a general, simple, and effective base-catalyzed halodeboronation that is amenable to the preparation of 125I-labeled products for SPECT applications.
