35106-84-4

Basic information

• Product Name: SALOR-INT L480363-1EA
• Synonyms: SALOR-INT L480363-1EA;1-(1-BROMOETHYL)-2-(BROMOMETHYL)BENZENE;1-broMoMethyl-2-(α-broMoethyl)benzene
• CAS NO: 35106-84-4
• Molecular Weight: 277.986
• Mol File: 35106-84-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: SALOR-INT L480363-1EA(CAS DataBase Reference)
• NIST Chemistry Reference: SALOR-INT L480363-1EA(35106-84-4)
• EPA Substance Registry System: SALOR-INT L480363-1EA(35106-84-4)

Safety Data

• Hazardous Substances Data: 35106-84-4(Hazardous Substances Data)

Upstream product

• 57259-71-9 1-(1-hydroxyethyl)-2-hydroxymethylbenzene 
• 7789-60-8 phosphorus tribromide 
• 35050-24-9 2-(vinyl)benzyl acetate 
• 577-56-0 2-acetyl-benzoic acid 
• 611-14-3 2-Ethyltoluene 
• 35106-83-3 o-(α-Bromoethyl)benzylalkoholacetat 
• 125593-33-1 2-ethoxymethyl-phenethyl alcohol 

Downstream Products

• 42142-17-6 1-(o-tolyl)ethanamine 
• 35106-79-7 4-methyl-3-(3,4,5-trimethoxy-benzoyl)-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 35106-78-6 3-(2-chloro-benzoyl)-4-methyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 35106-77-5 3-(4-chloro-benzoyl)-4-methyl-3,4-dihydro-1H-benzo[d][1,2]oxazine 
• 35106-72-0 3-Chloroformyl-4-methyl-3,4-dihydro-1H-2,3-benzoxazin 
• 1083-04-1 2-Phenyl-1,2,3,4-tetrahydro-isoarsinolin 
• 136103-76-9 1-mercaptomethyl-2-(α-mercaptoethyl)benzene 
• 19418-95-2 2-(2-ethylphenyl)acetic acid 
• 75820-08-5 1-methyl-2-(4-chloro-3-sulfamoylbenzamido)isoindoline 
• 932745-89-6 (2-benzyloxycarbonylamino-1-methyl-indan-2-yl)-phosphonic acid diethyl ester 
• 136103-73-6 4-methyl-cis-2-phenyl-1,3-dithia-5,6-benzocycloheptene 

Relevant articles and documents

ISOINDOLINE DERIVATIVES

The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

Formation of 4,5,6,7-tetrahydroisoindoles by palladium-catalyzed hydride reduction

(Chemical Equation Presented) Substituted 1,3-dihydro-2H-isoindoles (2, isoindolines) were prepared and subjected to palladium-catalyzed formate reduction. Alkyl isoindolines were reduced to 4,5,6,7-tetrahydro-2H-isoindoles (1). Only partial reduction was observed for 5-methoxyisoindoline, and 4-methoxy-, 5-carbomethoxy-, amino-, and amidoisoindolines were inert to the reaction. Halogen-substituted isoindolines were dehalogenated and reduced to 4,5,6,7-tetrahydro-2H-isoindoles. Isoindole 24 was also reduced to a mixture of an isoindoline and a 4,5,6,7-tetrahydro-2H-isoindole. In contrast, 2,3-dihydro-1H-indoles 21 underwent dehydrogenation to give thermodynamically stable indoles. Theoretical calculations show the significant difference in aromaticity between isoindoles and indoles, corresponding to the observed differences in reactivities. Tetrahydro-2H-isoindoles 1 were oxidized to 4,5,6,7-tetrahydroisoindole-1,3-diones in the presence of NBS and air.

4,5 Dihydroimidazole compounds which have useful pharmaceutical utility

A compound of formula (I): STR1 or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein: Z represents a residue of a substituted or unsubstituted aryl group, A1 represents a subst