35113-40-7

Basic information

• Product Name: 3-THIEN-2-YLISOXAZOL-5-AMINE
• Synonyms: 3-THIEN-2-YLISOXAZOL-5-AMINE;3-(Thiophene-2-yl)isoxazol-5-aMine;3-(2-THIENYL)-5-ISOXAZOLAMINE;5-amino-3-(2-thienyl)isoxazole
• CAS NO: 35113-40-7
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.2
• Mol File: 35113-40-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-THIEN-2-YLISOXAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-THIEN-2-YLISOXAZOL-5-AMINE(35113-40-7)
• EPA Substance Registry System: 3-THIEN-2-YLISOXAZOL-5-AMINE(35113-40-7)

Safety Data

• Hazardous Substances Data: 35113-40-7(Hazardous Substances Data)

Upstream product

• 151-50-8 potassium cyanide 
• 33898-90-7 2-Thenoylacetonitrile 

Downstream Products

• 1610549-05-7 5,6-diphenyl-N-[3-(2-thienyl)isoxazol-5-yl]furo[2,3-d]pyrimidin-4-amine 

Relevant articles and documents

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is

Hoveyda-Grubbs II Catalyst: A Useful Catalyst for One-Pot Visible-Light-Promoted Ring Contraction and Olefin Metathesis Reactions

A one-pot reaction to synthesize functionalized 2H-azirines through visible-light-mediated ring contraction and olefin metathesis of isoxazoles is described. Hoveyda-Grubbs II catalyst was found to function as a photocatalyst for these transformations, al

ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to isoxazolopyndine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the isoxazolopyndine compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.