35123-06-9

Basic information

• Product Name: Propanamide, 2-hydroxy-N,N-dimethyl- (9CI)
• Synonyms: Propanamide, 2-hydroxy-N,N-dimethyl- (9CI);Propanamide, 2-hydroxy-N,N-dimethyl-;2-Hydroxy-N,N-dimethylpropanamide;Ai3-15674;Lactamide, N,N-dimethyl- (6ci);N,N-Dimethyllactamide;2-hydroxy-N,N-dimethylpropanamide(SALTDATA: FREE)
• CAS NO: 35123-06-9
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• Product Categories: ACETYLGROUP
• Mol File: 35123-06-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 200.247 °C at 760 mmHg
• Flash Point: 74.907 °C
• Appearance: /
• Density: 1.034 g/cm³
• Vapor Pressure: 0.0815mmHg at 25°C
• Refractive Index: 1.45
• PKA: 13.34±0.20(Predicted)
• CAS DataBase Reference: Propanamide, 2-hydroxy-N,N-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-hydroxy-N,N-dimethyl- (9CI)(35123-06-9)
• EPA Substance Registry System: Propanamide, 2-hydroxy-N,N-dimethyl- (9CI)(35123-06-9)

Safety Data

• Hazardous Substances Data: 35123-06-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 1911, 1947 DOI: 10.1021/ja01200a020Tetrahedron Letters, 16, p. 1731, 1975

InChI:InChI=1/C5H11NO2/c1-4(7)5(8)6(2)3/h4,7H,1-3H3

Upstream product

• 758-96-3 N,N-dimethyl-propanamide 
• 13372-32-2 5-methyl-4-oxo-1,3-dioxolane 
• 124-40-3 dimethyl amine 
• 849585-22-4 LACTIC ACID 
• 95-96-5 D,L-lactide 
• 19432-30-5 Brenztraubensaeuredimethylamid 
• 547-64-8 methyl lactate 
• 97-64-3 ethyl 2-hydroxypropionate 

Downstream Products

• 6280-18-8 DL-2-acetoxy-propionic acid dimethylamide 
• 2680-03-7 N,N-Dimethylacrylamide 
• 193806-12-1 (R)-2-hydroxy-N,N-dimethylpropanamide 
• 31502-31-5 (S)-N,N-dimethyl lactamide 
• 1296198-59-8 C₁₁H₂₁NO₂ 

Relevant articles and documents

METHOD FOR PREPARING ALKYL LACTATE AND A METHOD FOR PREPARING LACTAMIDE USING THE SAME

This disclosure relates to a method for preparing alkyl lactate with high yield and high selectivity, comprising the step of reacting glycerol with water or alcohol in the presence of a catalyst. In addition, the present invention provides a method for efficiently preparing lactamide using the alkyl lactate.

PROCESS FOR MAKING AMIDES

Process for making an amide of a carboxylic acid by reacting an amine of the formula (I) H-NR1R2, the integers being defined as being equal or different, R1 being selected from C1-C4-alkyl, R2 being selected from hydrogen and C1-C4-alkyl, R1 and R2 being combined in a way that amine according to formula (I) has a lower boiling point than water, with a carboxylic acid with at least 3 carbon atoms per molecule, said carboxylic acid optionally bearing at least one alcoholic hydroxyl group per molecule, selecting a molar ratio of amine according to formula (I) to carboxylic acid in the range of from 1.5 : 1 to 1 : 1, comprising the following measures: (a) reacting amine according to formula (I) with said carboxylic acid at temperature and pressure conditions at which water and amine according to formula (I) are gaseous, wherein the reaction (a) is performed in a single reactor, (b) distilling off the water formed, together with unreacted amine according to formula (I), (c) separating unreacted amine according to formula (I) from the water and (d) re-introducing said amine according to formula (I) into the reaction mixture in measure (a).

METHOD OF PREPARING DIALKYL LACTAMIDES

A method of preparing dialyl lactamides. The method of preparing dialkyl lactamides includes preparing ammonium lactate by reacting at least one compound selected from the group consisting of lactic acid and esters thereof with at least one amine compound, preparing dialkyl lactamides by heat-treating the ammonium lactate, and adding at least one of a polymerization inhibitor and an anti-polymerization agent to a reaction mixture of at least one of the preparing of the ammonium lactate and the preparing of the dialkyl lactamides.