351464-82-9Relevant articles and documents
Lithium/DTBB-induced reduction of N-alkoxyamides and acyl azides
Yus, Miguel,Radivoy, Gabriel,Alonso, Francisco
, p. 914 - 918 (2007/10/03)
A series of N-alkoxyamides and N-methoxy-N-methylamides (Weinreb amides) have been subjected to dealkoxylation by reductive cleavage of the N-O bond with lithium powder and a catalytic amount of DTBB (10 mol%) at room temperature, leading to the corresponding amides. When the reaction is performed under reflux conditions, the corresponding alkanes, resulting from a formal deaminocarbonylation process, are obtained. This methodology applied to acyl azides furnished the corresponding primary amides.