35219-19-3

Basic information

• Product Name: 7-Methyl-8-phenyl-1,2,3,5-tetrahydroimidazo[1,2-a]pyridin-5-one
• Synonyms: 7-Methyl-8-phenyl-1,2,3,5-tetrahydroimidazo[1,2-a]pyridin-5-one
• CAS NO: 35219-19-3
• Molecular Weight: 226.278
• Mol File: 35219-19-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-Methyl-8-phenyl-1,2,3,5-tetrahydroimidazo[1,2-a]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methyl-8-phenyl-1,2,3,5-tetrahydroimidazo[1,2-a]pyridin-5-one(35219-19-3)
• EPA Substance Registry System: 7-Methyl-8-phenyl-1,2,3,5-tetrahydroimidazo[1,2-a]pyridin-5-one(35219-19-3)

Safety Data

• Hazardous Substances Data: 35219-19-3(Hazardous Substances Data)

Upstream product

• 59-98-3 tolazoline 
• 141-97-9 ethyl acetoacetate 
• 85920-63-4 5-(1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1068658-13-8 1-tert-butoxycarbonyl-2-benzyl-4,5-dihydroimidazole 
• 1068658-15-0 1-benzyloxycarbonyl-2-benzyl-4,5-dihydroimidazole 

Downstream Products

• 66066-54-4 1,7-dimethyl-8-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyridin-5-one 

Relevant articles and documents

Synthesis of imidazo[1,2-α]pyridines from unactivated 2-alkyl-4,5-dihydroimidazoles through conjugate N-addition

2-Alkyl-4,5-dihydroimidazoles undergo annulation with α,β-unsaturated aldehydes and ketones via conjugate addition of the N-1 nitrogen atom and subsequent enamine-aldol condensation of C(α) to form imidazo[1,2-α]pyridines having reversed regiochemistry of annulation from that observed with a dihydroimidazole carrying an activating group at C(α); annulation with β-ketoesters also affords imidazo[1,2-α]pyridines, but now with the same regiochemistry as found with a C(α)-activated dihydroimidazole and necessitating a revision of earlier reported structures. Dialkyl acetylenedicarboxylates undergo conjugate N-addition but act as 1,2- rather than 1,3-bis-electrophiles to form pyrrolo[1,2-α]imidazoles. The Royal Society of Chemistry 2000.