35244-51-0Relevant articles and documents
The γ-alkylation of cyclic β-ketoesters via their enamine derivatives
Gravel, Denis,Labelle, Marc
, p. 1874 - 1883 (2007/10/02)
The γ-alkylation - functionalization of cyclic β-ketoesters via their enamine derivatives is discussed with particular emphasis on their preparation from β-ketoesters and their reaction with various electrophiles such as electrophilic olefins, halogenoids, anmd allylic and benzylic halides.Although the amine ring size does not appear to affect reactivity to a great extent, the reaction is very sensitive to β-ketoester ring size, with six-membered rings giving the best results.In the latter case the alkylation-functionalization is general and specific to the γ-position and therefore provides an important complement to the dianion and related methodologies.
