35252-03-0

Basic information

• Product Name: Pyrido[2,3-b]pyrazin-2(1H)-one
• CAS NO: 35252-03-0
• Molecular Formula: C₇H₅N₃O
• Molecular Weight: 147.13
• Mol File: 35252-03-0.mol
• Article Data: 5

Chemical Properties

• Density: 1.479 g/cm³
• CAS DataBase Reference: Pyrido[2,3-b]pyrazin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-b]pyrazin-2(1H)-one(35252-03-0)
• EPA Substance Registry System: Pyrido[2,3-b]pyrazin-2(1H)-one(35252-03-0)

Safety Data

• Hazardous Substances Data: 35252-03-0(Hazardous Substances Data)

Usage

General Description

Pyrido[2,3-b]pyrazin-2(1H)-one is a chemical compound with the molecular formula C8H5N3O. It is a heterocyclic compound that contains a pyrazine ring fused to a pyridine ring with a carbonyl group. Pyrido[2,3-b]pyrazin-2(1H)-one has been studied for its potential as a pharmaceutical intermediate and as a building block for the synthesis of complex organic molecules. It has also been investigated for its potential biological activities, including as an antioxidant and an anti-inflammatory agent. Pyrido[2,3-b]pyrazin-2(1H)-one is of interest to researchers in the fields of medicinal chemistry and chemical synthesis.

Upstream product

• 452-58-4 2,3-Diaminopyridine 
• 563-96-2 2,2-dihydroxyacetic acid 
• 924-44-7 glyoxylic acid ethyl ester 
• 934993-79-0 2-chloro-3-hydrazinylpyrido[2,3-b]pyrazine 
• 25710-18-3 2,3-Dichloro-pyrido[2,3-b]pyrazine 

Downstream Products

• 70838-55-0 2-chloropyrido[2,3-b]pyrazine 

Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF

Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

Comparative Kinetic Studies on the Synthesis of Quinoxalinone Derivatives and Pyridopyrazinone Derivatives by the Hinsberg Reaction

Kinetic studies on the anelation of quinoxalinone derivatives 3a-c and pyridopyrazinone derivatives 5a-c and 6a-c synthesized by the Hinsberg reaction is reported. o-Phenylenediamine or 2,3-diaminopyridine were treated with bifunctional carbonyl compounds such as glyoxylic, pyruvic and benzoylformic acids under different experimental conditions.When pyridopyrazine derivatives were synthesized both position isomers were achieved applying regioselective reactions.Mixture were avoided by looking for special experimental conditions that led unambigously to only one of the components of the classic "Hinsberg mixture".Quinoxalinone derivatives 3a-c were obtained at room temperature in good yields (>90percent) using anhydrous methanol or ethanol as solvents.On the other hand, only pyridopyrazin-3(4H)-one (5a) was regioselectively attained in aqueous buffer of pH 7 while 3-methylpyridopyrazinone derivatives were regioselectively separated using anhydrous methanol for one isomer, 5b, and anhydrous chloroform for the other isomer, 6b, at room temperature.Yields were higher than 80percent.Reactions with benzoylformic acid did not give good yields and only 2-phenylpyridopyrazin-3(4H)-one (5c) could be obtained using anhydrous chloroform (yield pyrazin-3(4H)-one (5c) in good yields applying this technique.The other isomer, 3-phenylpyrazin-2(1H)-one (6c) was always formed together with the former isomer and could not be isolated from the mixture, when other solvents than chloroform were used as the reaction media.