352530-22-4

Basic information

• Product Name: 4-Fluoro-3-nitrophenylboronic acid
• Synonyms: 4-FLUORO-3-NITROPHENYLBORONIC ACID;4-FLUORO-3-NITROBENZENEBORONIC ACID;4-Fluoro-3-Nitrophenylboronic;3-Nitro-4-fluorophenylboronic acid;4-fiuoro-3-nitrophenylboronic acid;5-Borono-2-fluoronitrobenzene;Boronic acid,B-(4-fluoro-3-nitrophenyl)-
• CAS NO: 352530-22-4
• Molecular Formula: C₆H₅BFNO₄
• Molecular Weight: 184.92
• Product Categories: blocks;BoronicAcids;NitroCompounds;Boronic Acid
• Mol File: 352530-22-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 367 °C at 760 mmHg
• Flash Point: 175.7 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 4.95E-06mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.02±0.10(Predicted)
• CAS DataBase Reference: 4-Fluoro-3-nitrophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-nitrophenylboronic acid(352530-22-4)
• EPA Substance Registry System: 4-Fluoro-3-nitrophenylboronic acid(352530-22-4)

Safety Data

• Hazardous Substances Data: 352530-22-4(Hazardous Substances Data)

Usage

Uses

suzuki reaction

InChI:InChI=1/C6H5BFNO4/c8-5-2-1-4(7(10)11)3-6(5)9(12)13/h1-3,10-11H

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1020173-81-2 tert-butyl 1-(4-fluoro-3-nitrophenyl)-3-isopropyl-1H-pyrazole-5-carboxylate 
• 873566-75-7 (3-amino-4-fluoro-phenyl)boronic acid 

Relevant articles and documents

Synthesis of 3-amino-4-fluorophenylboronic acid method

The invention belongs to the field of synthesis of organic chemicals, and relates to a method for synthesizing 3-amino-4-fluorophenylboronic acid, which comprises the following steps: 1. preparing fluorobromobenzene into a Grignard reagent, and reacting with trimethyl borate to obtain an intermediate fluorophenylboronic acid A; 2. reacting the intermediate A with fuming nitric acid to generate an intermediate 3-nitro-4-fluorophenylboronic acid B; and 3. hydrogenating the intermediate B by using a palladium-on-carbon catalyst to generate the product 3-amino-4-fluorophenylboronic acid C. The synthesis method has the advantages of accessible raw materials and lower cost, is simple to operate, and provides a proper way for preparing 3-amino-4-fluorophenylboronic acid.