352647-04-2

Basic information

• Product Name: 2,6-bis(adamantan-1-yl)-4-bromophenol
• CAS NO: 352647-04-2
• Molecular Weight: 441.451
• Mol File: 352647-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-bis(adamantan-1-yl)-4-bromophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(adamantan-1-yl)-4-bromophenol(352647-04-2)
• EPA Substance Registry System: 2,6-bis(adamantan-1-yl)-4-bromophenol(352647-04-2)

Safety Data

• Hazardous Substances Data: 352647-04-2(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 768-95-6 1-adamanthanol 

Relevant articles and documents

Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4- bromophenol, A key intermediate of adapalene

A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable ion-exchange sulfonic acid resin in acetic acid.The sole byproduct of the adamantylation reaction,namely water,could be converted into the solvent acetic acid by addition of a slight excess of acetic anhydride during the work-up procedure,making the process waste-free except for regeneration of the ionexchange resin,and facilitating the recycling of the resin catalyst.The ion-exchange sulfonic acid resin catalyst could be readily recycled by filtration and directly reused at least ten times without a significant loss of activity.The key intermediate of adapalene,2-(1-adamantyl)-4-bromophenol,could be produced by means of this waste-free process.