35309-72-9

Basic information

• Product Name: 3-Bromo-N,N-diisopropylbenzamide
• Synonyms: 3-Bromo-N,N-diisopropylbenzamide
• CAS NO: 35309-72-9
• Molecular Formula: C₁₃H₁₈BrNO
• Molecular Weight: 284.2
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 35309-72-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 363.8°Cat760mmHg
• Flash Point: 173.8°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 1.76E-05mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Bromo-N,N-diisopropylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-N,N-diisopropylbenzamide(35309-72-9)
• EPA Substance Registry System: 3-Bromo-N,N-diisopropylbenzamide(35309-72-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 35309-72-9(Hazardous Substances Data)

Usage

Description

3-Bromo-N,N-diisopropylbenzamide, also known as Bromcarbanilide, is a white to off-white solid compound with the molecular formula C15H20BrNO. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and possesses potential antimicrobial and anti-inflammatory properties, making it a versatile compound in medicinal and agricultural applications.

Uses

Used in Pharmaceutical Industry:
3-Bromo-N,N-diisopropylbenzamide is used as an intermediate in the synthesis of various bioactive compounds and pharmaceuticals for its potential antimicrobial and anti-inflammatory properties.
Used in Agrochemical Industry:
3-Bromo-N,N-diisopropylbenzamide is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
It is important to handle and store 3-Bromo-N,N-diisopropylbenzamide in a cool, dry place away from direct sunlight and sources of ignition, and to take proper precautions when using this chemical to avoid irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C13H18BrNO/c1-9(2)15(10(3)4)13(16)11-6-5-7-12(14)8-11/h5-10H,1-4H3

Upstream product

• 585-76-2 m-bromobenzoic acid 
• 1711-09-7 3-bromobenzoyl chloride 
• 108-18-9 diisopropylamine 

Downstream Products

• 585-76-2 m-bromobenzoic acid 
• 35306-75-3 3-bromobenzoic acid isopropylamide 

Relevant articles and documents

Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic molecules are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chemistry.

Generation and suppression of 3-/4-functionalized benzynes using zinc ate base (TMP-Zn-ate): New approaches to multisubstituted benzenes

We present full details of our new methods for preparing functionalized benzynes with lithium di-alkyl(2,2,6,6-tetramethylpiperidino)zincate (R 2Zn(TMP)Li) through deprotonative zincation as a key reaction. In this system, by choosing appropriate ligands for the zincate, either regioselective zincation of functionalized haloaromatics or the generation of substituted benzynes can be controlled in good yields with excellent chemoselectivity, using the same substrate. Zincation with tBu 2Zn(TMP)Li followed by electrophilic trapping or zincation with Me2Zn(TMP)Li followed by nucleophilic or diene trapping is shown to be a powerful tool for the chemoselective preparation of 1,2,3-/1,2,4- trisubstituted benzene derivatives. These methods offer far greater generality than previous methods for the synthesis of multifunctionalized benzenes. Computational/theoretical studies of the reaction mechanism of this unique benzyne formation indicated that preferential coordination of the dialkylzinc moiety of zincate to halogen is the reason for the reduced activation energy of the elimination, that is, for the formation of the benzyne. The role of the ligands on Zn in accelerating/decelerating the elimination is also discussed.