35322-20-4

Basic information

• Product Name: 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER
• Synonyms: 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER;Benzenebutanoic acid, 4-Methoxy-.alpha.,.gaMMa.-dioxo-, ethyl es;Benzenebutanoic acid, 4-Methoxy-.alpha.,.gaMMa.-dioxo-, ethyl ester;Ethyl 4-Methoxy-a,g-dioxo-benzenebutanoate;ethyl 4-[4-methoxyphenyl]-2,4-dioxobutyrate
• CAS NO: 35322-20-4
• Molecular Formula: C₁₃H₁₄O₅
• Molecular Weight: 236.22
• Mol File: 35322-20-4.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 407°Cat760mmHg
• Flash Point: 182°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 7.79E-07mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER(35322-20-4)
• EPA Substance Registry System: 4-(4-METHOXY-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER(35322-20-4)

Safety Data

• Hazardous Substances Data: 35322-20-4(Hazardous Substances Data)

Usage

General Description

"4-(4-Methoxy-phenyl)-2,4-dioxo-butyric acid methyl ester" is a chemical compound with a molecular structure containing a 4-methoxyphenyl group and a 2,4-dioxo-butyric acid methyl ester group. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. This chemical may also have potential applications in research and development for its structural and functional properties. Additionally, it is important to handle this compound with care as it may have certain hazards associated with its handling and use.

InChI:InChI=1/C13H14O5/c1-3-18-13(16)12(15)8-11(14)9-4-6-10(17-2)7-5-9/h4-7H,3,8H2,1-2H3

Upstream product

• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 64-17-5 ethanol 
• 95-92-1 oxalic acid diethyl ester 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 83715-74-6 6-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-3-methylsulfanyl-4H-[1,2,4]triazin-5-one 
• 126839-71-2 1-(4-Fluoro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 55558-77-5 4-(4-methoxyphenyl)-2,4-dioxobutanoic acid 
• 129227-35-6 3-[2-(4-Methoxy-phenyl)-2-oxo-ethyl]-9H-1,2,4a,9-tetraaza-phenanthrene-4,10-dione 
• 618070-51-2 ethyl 3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxylate 
• 852816-12-7 ethyl 1-methyl-5-[4-(methyloxy)phenyl]-1H-pyrazole-3-carboxylate 
• 870703-95-0 C₁₁H₉NO₃ 
• 1378938-23-8 2-amino-3-cyano-7-dimethylamino-4-(5-(4-methoxyphenyl)isoxazol-3-yl)-4H-chromene 
• 1354822-64-2 ethyl 1-(1-methylethyl)-6-[4-(methyloxy)phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylate 
• 1006372-87-7 C₁₇H₁₃BF₂N₂O₃ 
• 66394-50-1 3,4-dihydro-3-[2-oxo-2-(4-methoxyphenyl)ethylidene]-2(1H)-quinoxalinone 

Relevant articles and documents

Synthesis and biological evaluation of chalcone-linked pyrazolo[1,5-: A] pyrimidines as potential anticancer agents

A series of pyrazolo[1,5-a]pyrimidines substituted at C5 with 1-phenylprop-2-en-1-one (6a-q) and 3-phenylprop-2-en-1-one (7a-k) was synthesized and evaluated for antiproliferative activity. Among them, 6h was found to be the most active compound against the MDA-MB-231 cell line with an IC50 of 2.6 μM. The antiproliferative activity of this series of compounds ranged from 2.6 to 34.9 μM against A549 (lung cancer), MDA-MB-231 (breast cancer) and DU-145 (prostate cancer) cell lines. FACS analysis revealed that these hybrids arrest the cell cycle at the subG1 phase. Western blot analysis and an immunofluorescence assay showed the inhibition of the EGFR and STAT3 axis, which plays an important role in cell survival and apoptosis. Western blot and RT-PCR analyses that displayed an increase in apoptotic proteins such as p53, p21 and Bax and a decrease in the anti-apoptotic proteins Bcl-2 and procaspase-9 confirmed the ability of these hybrids to trigger cell death by apoptosis. Molecular docking studies described the binding of these hybrids to the ATP binding site of EGFR.

Lewis acid-promoted synthesis of highly substituted pyrrole-fused benzoxazinones and quinoxalinones

A synthesis of a series of novel fused tricyclic heterocyclic compounds has been achieved in one-pot reaction set up starting from (E)-3-(2-oxo-2-phenylethylidene)indolin-2-one and 1,4-benzoxazinone/quinoxalinone derivatives promoted by tin(IV) chloride.

Synthesis, in vitro anticancer activity and in silico studies of certain isoxazole-based carboxamides, ureates, and hydrazones as potential inhibitors of VEGFR2

The ensuing research presents the results of in vitro anticancer activity of novel 28 compounds of isoxazole–based carboxamides 3(a-d); ureates 4(a-g), 5, 6, 7a,b, 8; and hydrazones 9(a-f), 10(a-d), 11a,b as potential inhibitors of VEGFR2. The carboxamide

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-