353746-54-0

Basic information

• Product Name: 2-(3,5-DIOXO-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)-PROPIONIC ACID
• Synonyms: 2-(3,5-DIOXO-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)PROPANOIC ACID;2-(3,5-DIOXO-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)-PROPIONIC ACID;2-(3,5-DIOXO-4-AZA-TRICYCLO[5.2.1.0]DEC-8-EN-4-YL)-PROPIONIC ACID;AKOS BBS-00002168;IFLAB-BB F0827-0191;AURORA 23298;ART-CHEM-BB B023290;OTAVA-BB BB7117320230
• CAS NO: 353746-54-0
• Molecular Formula: C12H13NO4
• Molecular Weight: 235.24
• Mol File: 353746-54-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3,5-DIOXO-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-DIOXO-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)-PROPIONIC ACID(353746-54-0)
• EPA Substance Registry System: 2-(3,5-DIOXO-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL)-PROPIONIC ACID(353746-54-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 353746-54-0(Hazardous Substances Data)

Usage

Structure

Tricyclic ring system and a carboxylic acid group
The compound consists of a complex arrangement of carbon atoms in three interlocking rings and a carboxyl functional group (-COOH).

Classification

Alpha amino acids and derivatives
It belongs to a class of organic compounds that include amino acids and their modified forms.

Natural occurrence

Not found in nature
This compound does not occur naturally and must be synthesized in a laboratory.

Synthesis

Laboratory setting
The synthesis of this compound requires controlled laboratory conditions and specific chemical reactions.

Potential applications

Medicinal chemistry
The complex structure of the compound suggests that it may have biological activity, which could be useful in the development of pharmaceuticals.

Further research

Necessary to determine potential uses and effects
Additional studies and tests are needed to explore the compound's properties, applications, and potential effects on biological systems.

Upstream product

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Relevant articles and documents

Modification of polyhedral oligomeric silsesquioxane derivatives with heck reaction as possible new bio-hybrid materials

The regioselective synthesis of Polyhedral oligomeric silsesquioxane (POSS)-based norbornyl imide derivatives through palladium catalyzed Heck coupling reaction was reported on an effective synthetic method to organic–inorganic bio-hybrids serving as advanced materials. The reaction of POSS-based imide derivatives with various aryl iodides catalyzed by palladium acetate in the presence of triethyl amine, as the base, in DMF afforded the products in moderate yields. All new POSS derivatives were structurally characterized by FTIR, 1H, 13C NMR, HRMS and GC/MS analyses.

Amide compounds for regulating WNT signal channel and application of compounds

The invention belongs to the technical field of medicine, and particularly relates to amide compounds for regulating a WNT signal channel and an application of the compounds. The compounds have a structure represented by a general formula I shown in the description.

Design, synthesis and mechanism of novel shikonin derivatives as potent anticancer agents

In this study, a series of novel shikonin derivatives (30-49) were designed and synthesized and their anti-proliferative activities were evaluated against five different cancer cell lines, including HeLa, HepG2, MCF-7, BGC and A549. Some of the compounds show strong anti-proliferative effects against HeLa, HepG2 and MCF-7 with IC50 values ranging from 1.26 to 18.50 μM and show lower side effects towards normal cell lines as compared to shikonin. Compared to other compounds and shikonin itself, compound 40 displayed much stronger anti-proliferative effects against various cancer cell lines. Furthermore, the flow cytometry results demonstrated that compound 40 could obviously induce apoptosis in a dose- and time-dependent manner and also cause cell cycle arrest at the G2/M phase. For further investigation of the aforementioned mechanisms, we performed Western blot experiments and found that the cleavage of PARP and upstream caspase-3 increased; moreover, caspase-9 was activated by cleavage but not caspase-8. These aforementioned results also indicate that compound 40 could induce caspase-9 involved apoptosis and G2/M phase cell cycle arrest via the P21, p-CDC2 (Tyr15) pathway independent of P53.