354118-71-1

Basic information

• Product Name: Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate
• Synonyms: Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate
• CAS NO: 354118-71-1
• Molecular Weight: 496.604
• Mol File: 354118-71-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate(354118-71-1)
• EPA Substance Registry System: Ethyl (3R,6S,2'R)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate(354118-71-1)

Safety Data

• Hazardous Substances Data: 354118-71-1(Hazardous Substances Data)

Upstream product

• 535-11-5 Ethyl 2-bromopropionate 
• 205517-34-6 (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione 

Downstream Products

• 354118-66-4 Ethyl (3R,6S,2'S)-2'-[N,N'-bis-p-methoxybenzyl-6-isopropylpiperazine-2,5-dion-3-yl]propionoate 

Relevant articles and documents

Enantiodiscrimination of racemic electrophiles by diketopiperazine enolates: asymmetric synthesis of methyl 2-amino-3-aryl-butanoates and 3-methyl-aspartates

Enolates of (S)-N,N′-bis-(p-methoxybenzyl)-3-iso-propylpiperazine-2,5-dione exhibit high levels of enantiodiscrimination in alkylations with (RS)-1-aryl-1-bromoethanes and (RS)-2-bromoesters, affording substituted diketopiperazines containing two new stereogenic centres in high de. Deprotection and hydrolysis of the resultant substituted diketopiperazines provides a route to the asymmetric synthesis of homochiral methyl 2-amino-3-aryl-butanoates and 3-methyl-aspartates in high de and ee.