354222-31-4

Basic information

• Product Name: 1-(2-chlorophenyl)ethyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazol-4-ylcarbamate
• Synonyms: 1-(2-chlorophenyl)ethyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazol-4-ylcarbamate
• CAS NO: 354222-31-4
• Molecular Weight: 405.281
• Mol File: 354222-31-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-chlorophenyl)ethyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazol-4-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chlorophenyl)ethyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazol-4-ylcarbamate(354222-31-4)
• EPA Substance Registry System: 1-(2-chlorophenyl)ethyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazol-4-ylcarbamate(354222-31-4)

Safety Data

• Hazardous Substances Data: 354222-31-4(Hazardous Substances Data)

Upstream product

• 18282-51-4 4-iodo-benzyl alcohol 
• 619-58-9 4-iodobenzoic acid 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 13524-04-4 2'-chloro-sec-phenethyl alcohol 
• 1243415-10-2 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylic acid 
• 1384485-34-0 methyl 5-(4-(chloromethyl)phenyl)-3-methylisoxazole-4-carboxylate 
• 1384485-33-9 methyl 5-(4-(hydroxymethyl)phenyl)-3-methylisoxazole-4-carboxylate 
• 1383717-87-0 methyl 3-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-prop-2-ynoate 

Downstream Products

• 355025-24-0 (+/-)-Ki16425 

Relevant articles and documents

Synthesis and biological evaluation of optically active Ki16425

An enantionselective synthesis of both enantiomers of Ki16425, which possesses selective LPA antagonistic activity, was achieved. The isoxazole core was constructed by a 1,3-dipolar cycloaddition of nitrile oxide with alkyne and condensation with the optically active α-phenethyl alcohol segment, which was prepared by an enantioselective reduction of arylmethylketone. Biological evaluation of both enantiomers of Ki16425 revealed that the (R)-isomer showed much higher antagonistic activity for LPA1 and LPA3 receptors.