35426-71-2

Basic information

• Product Name: 2,4-dinitrobenzenesulfonyl fluoride
• Synonyms: 2,4-dinitrobenzenesulfonyl fluoride
• CAS NO: 35426-71-2
• Molecular Weight: 250.164
• Mol File: 35426-71-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-dinitrobenzenesulfonyl fluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dinitrobenzenesulfonyl fluoride(35426-71-2)
• EPA Substance Registry System: 2,4-dinitrobenzenesulfonyl fluoride(35426-71-2)

Safety Data

• Hazardous Substances Data: 35426-71-2(Hazardous Substances Data)

Upstream product

• 1656-44-6 2,4-dinitrobenzenesulfonyl chloride 

Relevant articles and documents

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and optimization of covalent inhibitors of human neutrophil elastase (hNE). Evaluation of our ever-growing collection of SuFExable compounds toward various biological assays unexpectedly revealed a selective and covalent hNE inhibitor: benzene-1,2-disulfonyl fluoride. Synthetic derivatization of the initial hit led to a more potent agent, 2-(fluorosulfonyl)phenyl fluorosulfate with IC50 0.24 μM and greater than 833-fold selectivity over the homologous neutrophil serine protease, cathepsin G. The optimized, yet simple benzenoid probe only modified active hNE and not its denatured form.