354525-36-3

Basic information

• Product Name: Benzenemethanol, 3-methoxy-5-nitro- (9CI)
• Synonyms: Benzenemethanol, 3-methoxy-5-nitro- (9CI);(3-Methoxy-5-nitrophenyl)Methanol
• CAS NO: 354525-36-3
• Molecular Formula: C₈H₉NO₄
• Molecular Weight: 183.16136
• Product Categories: METHOXY
• Mol File: 354525-36-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanol, 3-methoxy-5-nitro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3-methoxy-5-nitro- (9CI)(354525-36-3)
• EPA Substance Registry System: Benzenemethanol, 3-methoxy-5-nitro- (9CI)(354525-36-3)

Safety Data

• Hazardous Substances Data: 354525-36-3(Hazardous Substances Data)

Usage

Derivative

It is derived from benzenemethanol.

Functional Groups

Methoxy group (–OCH3) at the 3-position
Nitro group (–NO2) at the 5-position

Usage

Commonly used in organic synthesis
Employed in pharmaceutical research

Potential Health Hazards

Identified as a potential mutagen and carcinogen
Caution required during handling and usage

Importance

Significant subject of study in chemistry and pharmacology

Upstream product

• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 
• 78238-13-8 3-methoxy-5-nitrobenzoic acid methyl ester 
• 2702-58-1 methyl 3,5-dinitrobenzoate 

Downstream Products

• 354512-22-4 3-methoxyl-5-nitrobenzaldehyde 
• 1108723-83-6 1-(azidomethyl)-3-methoxy-5-nitrobenzene 
• 65512-04-1 3-Hydroxy-5-pentyl-anilin 

Relevant articles and documents

Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as new antitubercular agents with potent in vitro and in vivo efficacy

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.625-6.25 μg/mL). The privileged compounds 3i and 3l showed moderate cytotoxicity against cell line A549. Compound 3l also exhibited potent in vivo inhibitory activity on a mouse infection model via the oral administration. The results demonstrated 3-hydroxyphenylcarbamates as a class of new antitubercular agents with good potential.

M-di-substituted phenol compound as well as preparation method thereof and application of tubercle bacillus resistance

The invention provides an m-di-substituted phenol compound with a general formula (I) as well as a preparation method and application thereof. The m-di-substituted phenol compound provided by the invention has a novel tubercle bacillus resistance drug parent nucleus structure and excellent tubercle bacillus resistance activity and especially has very strong inhibition activity on a drug-resistantvariant tubercle bacillus strain. The invention further provides the preparation method of the m-di-substituted phenol compound; the preparation method has the advantages that raw materials are cheapand easy to obtain, a high-toxicity and high-pollution reagent are not needed, reaction steps are simple and industrialized production can be realized; the m-di-substituted phenol compound has a goodmedicinal prospect.

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)