35453-44-2

Basic information

• Product Name: Benzoic acid, 2-(2,2,2-trifluoroethoxy)-, methyl ester
• CAS NO: 35453-44-2
• Molecular Formula: C10H9F3O3
• Molecular Weight: 234.175
• Mol File: 35453-44-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(2,2,2-trifluoroethoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(2,2,2-trifluoroethoxy)-, methyl ester(35453-44-2)
• EPA Substance Registry System: Benzoic acid, 2-(2,2,2-trifluoroethoxy)-, methyl ester(35453-44-2)

Safety Data

• Hazardous Substances Data: 35453-44-2(Hazardous Substances Data)

Upstream product

• 610-94-6 2-bromobenzoic acid methyl ester 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 119-36-8 methyl salicylate 

Downstream Products

• 50778-72-8 2-(2,2,2-trifluoroethoxy)benzoic acid hydrazide 
• 35480-46-7 2-(2,2,2-Trifluoroethoxy)benzoic acid 

Relevant articles and documents

Well-defined copper(I) fluoroalkoxide complexes for trifluoroethoxylation of aryl and heteroaryl bromides

Copper(I) fluoroalkoxide complexes bearing dinitrogen ligands were synthesized and the structure and reactivity of the complexes toward trifluoroethoxylation, pentafluoropropoxylation, and tetrafluoropropoxylation of aryl and heteroaryl bromides were investigated. Efficiency drive: A series of copper(I) fluoroalkoxide complexes bearing N,N ligands have been prepared and structurally characterized. These well-defined complexes serve as efficient reagents for the fluoroalkoxylation of aryl and heteroaryl bromides to produce a wide range of trifluoroethyl, pentafluoropropyl, and tetrafluoropropyl (hetero)aryl ethers in good to excellent yields.

Transition-Metal-Mediated Synthesis of Trifluoroethyl Aryl Ethers

A series of well-defined copper(I) fluoroalkoxide complexes, [(phen)2Cu][OCH2RF], have been shown to undergo trifluoroethoxylation, pentafluoropropoxylation, and tetrafluoropropoxylation with aryl and heteroaryl bromides to generate the corresponding trifluoroethyl, pentafluoropropyl, and tetrafluoropropyl (hetero)aryl ethers in good to excellent yields. The reaction tolerates a variety of functional groups and demonstrates efficient scalability and practicality.

Polyfluoroalkoxy-substituted aromatic carboxylic amides and hydrozides

Acyl halides, esters, amides, hydrazides and salts as well as the acid form derived from aromatic acids substituted by polyfluoroalkoxy groups. These compounds are valuable as synthetic intermediates in the preparation of physiologically active compounds.