354587-77-2

Basic information

• Product Name: 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 354587-77-2
• Molecular Formula: C₁₃H₁₉N₃O₃S
• Molecular Weight: 0
• Product Categories: pharmacetical
• Mol File: 354587-77-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 437.7°C at 760 mmHg
• Flash Point: 218.5°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 7.3E-08mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester(354587-77-2)
• EPA Substance Registry System: 4-(5-Formyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester(354587-77-2)

Safety Data

• Hazardous Substances Data: 354587-77-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H19N3O3S/c1-13(2,3)19-12(18)16-6-4-15(5-7-16)11-14-8-10(9-17)20-11/h8-9H,4-7H2,1-3H3

Upstream product

• 474417-23-7 tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate 
• 68-12-2 N,N-dimethyl-formamide 
• 898259-69-3 4-(5-hydroxymethyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 42270-37-1 1-thiazol-2-yl-piperazine 

Relevant articles and documents

SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

PIPERIDINE OR PIPERAZINE LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to piperidine or piperazine linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.

Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors

We have designed and synthesized a series of structurally novel hydroxamic acid-based histone deacetylase (HDAC) inhibitors characterized by a zinc chelating head group attached directly to a thiazole ring. The thiazole ring connects to a piperazine spacer, which is capped with a sulfonamide group. These novel molecules potently inhibit an HDAC enzyme mixture derived from HeLa cervical carcinoma cells and show potent antiproliferative activity against the breast cancer cell line MCF7.