354806-68-1

Basic information

• Product Name: N-(benzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine
• Synonyms: N-(benzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine
• CAS NO: 354806-68-1
• Molecular Weight: 407.416
• Mol File: 354806-68-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(benzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine(354806-68-1)
• EPA Substance Registry System: N-(benzyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine(354806-68-1)

Safety Data

• Hazardous Substances Data: 354806-68-1(Hazardous Substances Data)

Upstream product

• 342651-55-2 2-(methylsulfonyl)-4-[4-(methylsulfonyl)-phenyl]-6-(trifluoromethyl)pyrimidine 
• 100-46-9 benzylamine 
• 1778-09-2 4-(Methylthio)acetophenone 
• 134731-32-1 1-[4-(methylthio)phenyl]-4,4,4-trifluorobutane-1,3-dione 
• 342651-54-1 2-(methylthio)-4-[4-(methylthio)phenyl]-6-(trifluoromethyl) pyrimidine 

Relevant articles and documents

Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold

Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental da

Pyrmidine derivatives as selective inhibitors of cox-2

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl, R3 is C1-6alkyl or NH