354806-78-3Relevant articles and documents
Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold
Tietz, Ole,Sharma, Sai Kiran,Kaur, Jatinder,Way, Jenilee,Marshall, Alison,Wuest, Melinda,Wuest, Frank
, p. 8052 - 8064 (2013/12/04)
Cyclooxygenase (COX) is the key enzyme within the complex conversion of arachidonic acid into prostaglandins (PGs). Inhibitors of this enzyme represent a particularly promising class of compounds for chemoprevention and cancer therapy. The experimental da
Pyrmidine derivatives as selective inhibitors of cox-2
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, (2008/06/13)
The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl, R3 is C1-6alkyl or NH