354807-12-8

Basic information

• Product Name: 1H-Indole, 1-hydroxy-6-nitro-
• CAS NO: 354807-12-8
• Molecular Formula: C8H6N2O3
• Molecular Weight: 178.147
• Mol File: 354807-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-hydroxy-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-hydroxy-6-nitro-(354807-12-8)
• EPA Substance Registry System: 1H-Indole, 1-hydroxy-6-nitro-(354807-12-8)

Safety Data

• Hazardous Substances Data: 354807-12-8(Hazardous Substances Data)

Upstream product

• 19727-83-4 6-nitroindoline 

Downstream Products

• 4769-96-4 6-nitroindole 
• 749926-77-0 1-benzyloxy-6-nitroindole 
• 512773-79-4 4-amino-3-p-chlorophenoxy-2-p-chlorophenoxymethyl-7-nitropyrimido[1,2-a]indole-10-carbaldehyde 
• 512773-83-0 4-amino-3-p-chIorophenoxy-2-p-chIorophenoxymethyI-10-methyl-7-nitropyrimido[1,2-a]indole 
• 749926-78-1 1-benzyloxy-6-nitroindole-3-carbaldehyde 

Relevant articles and documents

Nucleophilic substitution reaction of 1-methoxy-6-nitro-indole

Nucleophilic substitution reaction of 1-methoxy-6-nitroindole (1) was examined. In the reaction with sodium methoxide or sodium cyanide as a nucleophile, 2- and 3-methoxy-6-nitroindoles, and 7-cyano-6-nitroindole were obtained, respectively. A novel methylene homologation at the 3-position was found in the reaction of 1 with sodium methyl sulfide or potassium salt of diethyl malonate to give 3-methylthiomethytyl-6-nitroindole and its 2-methylthio derivative, and diethyl 2-(6-nitroindol-3-yl)methylmalonate, respectively. Possible reaction mechanism is discussed.