35581-10-3

Basic information

• Product Name: 2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID
• Synonyms: 2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID;2-Amino-6-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic ac
• CAS NO: 35581-10-3
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.25
• Mol File: 35581-10-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID(35581-10-3)
• EPA Substance Registry System: 2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID(35581-10-3)

Safety Data

• Hazardous Substances Data: 35581-10-3(Hazardous Substances Data)

Usage

General Description

2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID is a chemical compound with a complex structure, containing an amino group, a methoxy group, and a carboxylic acid group attached to a tetrahydro naphthalene ring. 2-AMINO-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID may have potential pharmaceutical applications, as it contains a carboxylic acid group that could be involved in drug-receptor interactions. Additionally, the presence of the amino and methoxy groups may also confer biological activity. Further research and testing would be necessary to determine the specific properties and potential uses of this compound.

Upstream product

• 144646-02-6 3',4'-dihydro-6'-methoxyspiro-2,5-dione 
• 2472-22-2 6-methoxy-2-tetralone 

Downstream Products

• 144646-20-8 2-benzamido-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylic acid 
• 87063-11-4 methyl 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride 
• 144646-29-7 methyl 2-benzamido-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylate 
• 144731-98-6 N^2.2-<(S)-2-benzamido-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carbonyl>-(S)-phenylalanyl-(S)-phenylalanine N^1.3,N^1.3-(tetramethylene)amide 
• 144646-44-6 N^2.2-<(R)-2-benzamido-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carbonyl>-(S)-phenylalanyl-(S)-phenylalanine N^1.3,N^1.3-(tetramethylene)amide 
• 172168-06-8 C₁₉H₁₇NO₃ 
• 98569-15-4 (R)-2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid 
• 98569-07-4 (S)-2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid 

Relevant articles and documents

Deltorphin II analogues with 6-hydroxy-2-aminotetralin-2-carboxylic acid in position 1

Two approaches to the design of very active and highly selective δ opioid peptides were used to obtain new deltorphin analogues with altered hydrophobic and stereoelectronic properties. Deltorphin II analogues were synthesized with the substitution of Ile instead of Val at positions 5 and 6 in the address domain and 6-hydroxy-2-aminotetralin-2-carboxylic acid (Hat) instead of Tyr1 in the message domain. In the radioreceptor-binding studies, in which type-specific tritiated opioid ligands were used, (R)- and (S)-Hat- deltorphins exhibited similar K(i) values, revealing high δ selectivity. The peptides displayed agonist properties in the in vitro bioassay, with IC50 values in the subnanomolar range in the mouse vas deferens assay and in the micromolar or higher range in the guinea pig ileum assay, again demonstrating a high selectivity toward δ receptors. The agonist property of the new ligands was confirmed by means of [35S]GTPγS-binding experiments in membranes of the rat frontal cortex.