35653-54-4

Basic information

• Product Name: 1-BENZYL-3-PHENETHYL-2-THIOUREA
• Synonyms: 1-BENZYL-3-PHENETHYL-2-THIOUREA;1-benzyl-3-(2-phenylethyl)thiourea
• CAS NO: 35653-54-4
• Molecular Formula: C₁₆H₁₈N₂S
• Molecular Weight: 270.39
• Mol File: 35653-54-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 116-117°C
• Boiling Point: 419.7 °C at 760 mmHg
• Flash Point: 207.7 °C
• Appearance: /
• Density: 1.133 g/cm³
• Vapor Pressure: 2.97E-07mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 1-BENZYL-3-PHENETHYL-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3-PHENETHYL-2-THIOUREA(35653-54-4)
• EPA Substance Registry System: 1-BENZYL-3-PHENETHYL-2-THIOUREA(35653-54-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 35653-54-4(Hazardous Substances Data)

Usage

General Description

1-Benzyl-3-phenethyl-2-thiourea is a chemical compound that is primarily utilized for its inhibitory properties. It is often used as a selective and potent inhibitor of arylalkylamine N-acetyltransferase, an enzyme that plays a critical role in the biosynthesis of melatonin in the pineal gland. This chemical is known for its powerful bioactivities and has been extensively studied for potential therapeutic uses. However, its exposure should be limited and carefully controlled due to potential toxicity. Like with many chemical compounds, it needs to be handled with precaution - using the recommended protective equipment and following standard safety procedures.

InChI:InChI=1/C16H18N2S/c19-16(18-13-15-9-5-2-6-10-15)17-12-11-14-7-3-1-4-8-14/h1-10H,11-13H2,(H2,17,18,19)

Upstream product

• 2257-09-2 Phenethyl isothiocyanate 
• 100-46-9 benzylamine 
• 59795-89-0 phenethyl isocyanide 
• 88333-03-3 Benzyl isocyanide 
• 64-04-0 phenethylamine 
• 622-78-6 Benzyl isothiocyanate 

Relevant articles and documents

Continuous-flow synthesis of thioureas, enabled by aqueous polysulfide solution

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

Pos [...] 4 group metal olefin polymerization catalyst

Embodiments are directed to phosphaguanidine metal complexes of formula I and using those complexes in α-olefin polymerization systems.

Synthesis and biological evaluation of new 2,3-dihydrothiazole derivatives for antimicrobial, antihypertensive, and anticonvulsant activities

A novel series of 2-arylimino-2,3-dihydrothiazole derivatives, substituted in the 3-position with a β-phenethyl moiety and the 4-position with substituted aryl functions, was synthesized as potential antimicrobial, antihypertensive and anticonvulsive agen