35664-66-5Relevant articles and documents
Copper-catalyzed meta-selective arylation of phenol derivatives: An easy access to m-aryl phenols
Maraswami, Manikantha,Hirao, Hajime,Loh, Teck-Peng
, p. 2302 - 2309 (2021)
Achieving selective meta-functionalization of phenols is a significant challenge. Accessing such compounds generally needs elevated temperature or incorporation of complex templates. Here, we report a general approach to achieve meta-arylated phenols with a simple and common directing group. This coppercatalyzed protocol proceeds with complete meta-selectivity and tolerates a variety of functional groups in both coupling partners. Computational studies have revealed that the reaction proceeded via a Heck-like pathway.
