356783-31-8

Basic information

• Product Name: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-
• Synonyms: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-;6-fluoro-3-oxo-3,4-dihydropyrazine-2-carbonitrile;6-Fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile;6-fluoro-3-hydroxypyrazine-2-carbonitrile
• CAS NO: 356783-31-8
• Molecular Formula: C₅H₂FN₃O
• Molecular Weight: 139.0872832
• Mol File: 356783-31-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• PKA: 7.74±0.60(Predicted)
• CAS DataBase Reference: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-(356783-31-8)
• EPA Substance Registry System: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-(356783-31-8)

Safety Data

• Hazardous Substances Data: 356783-31-8(Hazardous Substances Data)

Usage

Description

2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxois a chemical compound with the appearance of a pale yellow to light yellow solid. It is primarily known for its role in the synthesis of pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxois used as a key intermediate in the synthesis of Favipiravir (F103350), an antiviral medication. Its chemical structure allows it to serve as a building block for the development of this drug, which is particularly effective against certain viral infections.

Melting Point

126 - 129℃

Upstream product

• 98142-97-3 3,6-dioxopiperazine-2-carboxamide 
• 41394-71-2 2-(chloroacetylamino)propanedioic acid diethyl ester 
• 1023813-21-9 3,6-dichloropyrazine-2-carboxamide 
• 356783-16-9 3,6-dichloropyrazine-2-carbonitrile 
• 18960-19-5 1,4-dioxopyrazinamide 
• 98-96-4 pyrazinamide 
• 1374986-06-7 C₇H₄FN₃O₃ 
• 1374986-05-6 methyl-5-chloroisoxazolo[4,5-b]pyrazine-3-carboxylate 
• 1374986-04-5 C₇H₅N₃O₄ 
• 1374986-03-4 C₁₁H₁₇N₃O₆ 
• 1374986-37-4 C₈H₉N₃O₅ 
• 1374986-35-2 C₈H₁₀N₂O₄ 
• 1374986-21-6 C₁₀H₁₀FN₃O₃ 
• 1374986-20-5 C₁₀H₁₀FN₃O₃ 

Downstream Products

• 259793-96-9 favipiravir 

Relevant articles and documents

Scalable synthesis of favipiravir: Via conventional and continuous flow chemistry

Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production. This journal is

PROCESS FOR THE PREPARATION OF 3,6-DICHLOROCYANO PYRAZINE, 3,6-DIOXOPIPERAZINE DERIVATIVES AND PRODUCTION OF FAVIPIRAVIR THEREOF

The present invention relates to a method of preparing derivatives of 3,6-dichlorocyano pyrazine, 3,6-dioxopiperizin and the production of favipiravir by cyclization and chlorination mediated by ammonia or amine using POCl3 in the presence of pyridine or PCl5. [Formula] In derivatives of 3,6-dioxopiperazine (III), X represents CN, CONH2 or COOR2', R1, R 2 and R2' are individually selected from H, alkyl C1-C12, COOR3 and SO2R3, R 3 being a linear or branched lower alkyl substituted or unsubstituted.

Preparation method of 6 -fluoro -3 -hydroxypyrazine -2 - formamide

The invention provides a preparation method of a pyrazine compound represented by the formula (I). To the invention, 6 -fluoro -3 -hydroxypyrazine -2 - methyl cyanide is used as a starting material, dimethyl sulfoxide is added under the conditions of hydrogen peroxide and sodium hydroxide, so that generation of oxygen in the system is avoided, and the production safety is greatly improved. The method provided by the invention is safe and suitable for industrial amplification, and has great help for industrial mass production of laprevir API.