35691-30-6

Basic information

• Product Name: DIETHYL 1,2,3,6-TETRAHYDROPYRIDAZINE-1,2-DICARBOXYLATE
• Synonyms: DIETHYL 1,2,3,6-TETRAHYDROPYRIDAZINE-1,2-DICARBOXYLATE;BUTTPARK 94\04-73;diethyl 3,6-dihydropyridazine-1,2-dicarboxylate
• CAS NO: 35691-30-6
• Molecular Formula: C₁₀H₁₆N₂O₄
• Molecular Weight: 228.25
• Mol File: 35691-30-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 111 °C
• Flash Point: 128.2 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.00236mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: DIETHYL 1,2,3,6-TETRAHYDROPYRIDAZINE-1,2-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 1,2,3,6-TETRAHYDROPYRIDAZINE-1,2-DICARBOXYLATE(35691-30-6)
• EPA Substance Registry System: DIETHYL 1,2,3,6-TETRAHYDROPYRIDAZINE-1,2-DICARBOXYLATE(35691-30-6)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 35691-30-6(Hazardous Substances Data)

Usage

General Description

DIETHYL 1,2,3,6-TETRAHYDROPYRIDAZINE-1,2-DICARBOXYLATE is a chemical compound with the molecular formula C12H20N2O4. It is a synthetic organic compound commonly used in the pharmaceutical industry as an intermediate for the production of various drugs. It is a diester of tetrahydropyridazine-1,2-dicarboxylic acid and is typically used as a building block in the synthesis of other organic compounds. This chemical has potential applications in the development of new drugs and has been studied for its possible therapeutic properties. However, it is important to handle this compound with care and follow proper safety protocols, as it may pose health and environmental risks if mishandled.

InChI:InChI=1/C10H16N2O4/c1-3-15-9(13)11-7-5-6-8-12(11)10(14)16-4-2/h5-6H,3-4,7-8H2,1-2H3

Upstream product

• 4143-61-7 diethyl diazodicarboxylate 
• 106-99-0 buta-1,3-diene 
• 1972-28-7 diethylazodicarboxylate 
• 4143-60-6 Diethyl azodicarboxylate 
• 77-79-2 3-Sulfolene 

Downstream Products

• 52944-50-0 tetrahydro-1,2-pyridazinedicarboxylic acid,diethyl ester 
• 26163-36-0 1,2-Dimethyl-1,2,3,6-tetrahydropyridazin 
• 1313705-27-9 1,2-diethyl 4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]tetrahydro-1,2-pyridazinedicarboxylate 
• 59925-42-7 2-phenylthiocarbamoyl-tetrahydro-pyridazine-1-carboxylic acid ethyl ester 
• 5740-50-1 1-ethoxycarbonylhexahydropyridazine 
• 132846-75-4 (2-Chloro-phenyl)-carbamic acid 1,2-dimethyl-hexahydro-pyridazin-4-yl ester 
• 132846-73-2 (4-Ethoxy-phenyl)-carbamic acid 1,2-dimethyl-hexahydro-pyridazin-4-yl ester 
• 132846-72-1 (4-Methoxy-phenyl)-carbamic acid 1,2-dimethyl-hexahydro-pyridazin-4-yl ester 
• 132846-68-5 o-Tolyl-carbamic acid 1,2-dimethyl-hexahydro-pyridazin-4-yl ester 
• 132846-70-9 p-Tolyl-carbamic acid 1,2-dimethyl-hexahydro-pyridazin-4-yl ester 
• 95634-04-1 (Z)-N'-Benzyl-N,N-dimethyl-but-2-ene-1,4-diamine 
• 159583-31-0 4-nitro-N-(1,2-dimethyl-4-piperidazyl)benzamide 
• 159583-29-6 1,2-dimethyl-4-aminopiperidazine 

Relevant articles and documents

Inactivation of Cytochrome P-450 by a Catalytically Generated Cyclobutadiene Species

2,3-Bis(carbethoxy)-2,3-diazabicyclohex-5-ene (DDBCH), synthesized by a route analogues to that reported for the preparation of the bis(carbomethoxy) analogue, inactivates the phenobarbital-inducible cytochrome P-450 isozymes of rat liver in a time-, NADPH-, and oxygen-dependent manner.The enzymes are protected by carbon monoxide and competitive alternative substrates but not by glutathione.The cyclobutenyl ? bond and the diazabicyclo skeleton are required for destructive activity, but hydrolytic removal of the carbamate groups is not.Enzyme inactivation reflects alkylation of the prosthetic heme group of the enzyme by a catalytically generated reactive species.The alkylated prosthetic group has been isolated and has been characterized, after demetallation and esterification, as N-(2-cyclobutenyl)protoporphyrin IX.The N-alkyl group is primarily located on the nitrogen of pyrrole ring D.DDBCH is thus oxidized by cytochrome P-450 to a cyclobutadienoid species that alkylates the prosthetic heme group.

β-ELIMINIERUNG AN QUARTAEREN HYDRAZINIUMSALZEN, EINE NEUE METHODE ZUR DARSTELLUNG UNSYMMETRISCH ALKYLIERTER DIAMINE

Deprotonation of the hydrazinium salts 5-8 with concomitant N-N cleavage resulted in the formation of imines, which were trapped by external nucleophiles.