357915-19-6

Basic information

• Product Name: 2-bromo-1-(2,4-dichloro-5-fluorophenyl)ethanone
• Synonyms: 2-bromo-1-(2,4-dichloro-5-fluorophenyl)ethanone
• CAS NO: 357915-19-6
• Molecular Formula: C₈H₄BrCl₂FO
• Molecular Weight: 285.9251632
• Mol File: 357915-19-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-1-(2,4-dichloro-5-fluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(2,4-dichloro-5-fluorophenyl)ethanone(357915-19-6)
• EPA Substance Registry System: 2-bromo-1-(2,4-dichloro-5-fluorophenyl)ethanone(357915-19-6)

Safety Data

• Hazardous Substances Data: 357915-19-6(Hazardous Substances Data)

Upstream product

• 704-10-9 2,4-dichloro-5-fluoroacetophenone 

Downstream Products

• 934385-01-0 C₁₂H₁₄Cl₂FNO₂ 
• 1155458-58-4 2,2'-(2,6-bis(2,4-dichloro-5-fluorophenyl)piperazine-1,4-diyl)diethanol 
• 1415720-88-5 C₁₉H₁₄BrCl₂FN₄S 
• 1415720-79-4 C₁₉H₁₄Cl₃FN₄S 
• 1415720-71-6 C₁₉H₁₅Cl₂FN₄S 
• 1243257-36-4 2-[2-(2,4-dichloro-5-fluorophenyl)morpholino-4-yl]-ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride 
• 1256383-14-8 C₁₈H₁₀Cl₄FN₃O₂S 
• 1256383-09-1 C₁₈H₁₁Cl₃FN₃O₂S 
• 1144511-85-2 C₁₆H₇Cl₄F₂N₃OS 

Relevant articles and documents

Diaryl-containing imidazole compound and preparation method and medical application thereof

The invention discloses a diaryl-containing imidazole compound. The invention further discloses application of the diaryl-containing imidazole compound to preparation of drugs for preventing or treating Alzheimer's disease. The inventor screens butyrylcholine esterase and IDO1 as carriers for inhibiting the activity to evaluate the effect of the diaryl imidazole compound to treat Alzheimer's disease, and finds that the diaryl imidazole compound has good in vitro activity, and can be further developed as a precursor substance for performing the Alzheimer's disease resistant effect by inhibitingthe activity of cholinesterase. (The formula is shown in the description).

Novel synthetic approach toward C-substituted piperazine derivatives via C-N bonds formation of α-bromoarylethanones and ethanolamine

A new method for the synthesis of novel C-substituted piperazine derivatives bearing aryl substituents on 2,6-C positions has been developed by one-pot three-component sequential reaction of α-bromoarylethanones with ethanolamine in the presence of formic

Synthesis, spectral characterization and biological evaluation of a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl)propan-2-yl]-7H-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazines

On account of the reported anticancer activity of triazolothiadiazines, we have synthesized a novel series of 6-arylsubstituted-3-[2-(4-substitutedphenyl) propan-2-yl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and tested for in-vitro cytotoxicity by trypan blue exclusion and MTT assay. These compounds were also evaluated for their in-vivo anthelmintic activity, as well as in-vitro antimicrobial studies. Amongst the tested compounds, the compound 7j was the most promising cytotoxic agent with IC50 value of 10.54 μM in MCF-7 cells. The compounds 7l and 7q exhibited excellent anthelmintic activity. The compounds 7d, 7f, 7j, 7l, 7o, 7p and 7r showed good antibacterial activity, whereas compounds 7e and 7k exhibited excellent antifungal activity. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and LCMS analysis.