357952-86-4

Basic information

• Product Name: (S)-(+)-1-(4-Fluorophenyl)-2-(p-tolylsulfonyloxy)ethanol
• Synonyms: (S)-(+)-1-(4-Fluorophenyl)-2-(p-tolylsulfonyloxy)ethanol
• CAS NO: 357952-86-4
• Molecular Weight: 310.346
• Mol File: 357952-86-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-(+)-1-(4-Fluorophenyl)-2-(p-tolylsulfonyloxy)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1-(4-Fluorophenyl)-2-(p-tolylsulfonyloxy)ethanol(357952-86-4)
• EPA Substance Registry System: (S)-(+)-1-(4-Fluorophenyl)-2-(p-tolylsulfonyloxy)ethanol(357952-86-4)

Safety Data

• Hazardous Substances Data: 357952-86-4(Hazardous Substances Data)

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 357952-79-5 1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone 

Downstream Products

• 473552-27-1 (S)-(+)-2-amino-1-(p-fluorophenyl)ethanol 
• 297765-48-1 (1S)-2-azido-1-(4-fluorophenyl)ethan-1-ol 
• 18511-62-1 (2S)-2-(4-fluorophenyl)oxirane 

Relevant articles and documents

Diastereoselective Alkene Hydroesterification Enabling the Synthesis of Chiral Fused Bicyclic Lactones

Palladium-catalysed diastereoselective hydroesterification of alkenes assisted by the coordinative hydroxyl group in the substrate afforded a variety of chiral γ-butyrolactones bearing two stereocenters. Employing the carbonylation-lactonization products as the key intermediates, the route from the alkenes with single chiral center to chiral THF-fused bicyclic γ-lactones containing three stereocenters was developed.

Convenient synthesis of optically active 1,2-diol monosulfonates and terminal epoxides via oxazaborolidine-catalyzed asymmetric borane reduction of α-sulfonyloxy ketones

A very convenient asymmetric synthesis of 1,2-diol monosulfonates and terminal epoxides with high optical purity via oxazaborolidine-catalyzed asymmetric borane reduction of α-sulfonyloxy ketones using N-ethyl-N-isopropylaniline-borane complex as borane carrier has been developed.