3584-66-5 Usage
Description
5-CHLORO-2-(TRICHLOROMETHYL)BENZIMIDAZOLE is a chemical compound that has been studied for its effect on the binding affinity of human growth hormone (hGH) to the extracellular domain of the hGH receptor. 5-CHLORO-2-(TRICHLOROMETHYL)BENZIMIDAZOLE may have potential applications in various fields due to its interaction with hGH and its receptor.
Uses
Used in Pharmaceutical Industry:
5-CHLORO-2-(TRICHLOROMETHYL)BENZIMIDAZOLE is used as a research compound for studying the interaction between human growth hormone (hGH) and its receptor. Understanding this interaction can provide insights into the development of new drugs or therapies targeting the hGH receptor, which may have implications for treating various growth-related disorders or conditions.
Used in Biomedical Research:
In the field of biomedical research, 5-CHLORO-2-(TRICHLOROMETHYL)BENZIMIDAZOLE can be utilized as a tool to investigate the molecular mechanisms underlying the binding affinity of hGH to its receptor. This knowledge can contribute to the advancement of our understanding of growth hormone signaling pathways and their role in health and disease.
Please note that the provided materials do not mention any specific applications of 5-CHLORO-2-(TRICHLOROMETHYL)BENZIMIDAZOLE in different industries. The uses listed above are inferred based on the general description and potential implications of the compound's interaction with hGH and its receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 3584-66-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,8 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3584-66:
(6*3)+(5*5)+(4*8)+(3*4)+(2*6)+(1*6)=105
105 % 10 = 5
So 3584-66-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H4Cl4N2/c9-4-1-2-5-6(3-4)14-7(13-5)8(10,11)12/h1-3H,(H,13,14)
3584-66-5Relevant articles and documents
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists
Terzioglu, Nalan,Van Rijn, Richard M.,Bakker, Remko A.,De Esch, Iwan J.P.,Leurs, Rob
, p. 5251 - 5256 (2004)
We describe the structure-activity relationships for a series of ligands structurally related to the recently identified (5-chloro-1H-indol-2-yl)-(4- methyl-piperazin-1-yl)-methanone (1) as histamine H4 receptor (H 4R) antagonists. Furthermore, we identified related benzimidazoles as novel lead compounds for the H4R. The ligands have been evaluated by radioligand displacement studies and functional assays for their interaction with both the human histamine H3 and H4 receptors and exhibit pKi values up to 7.5 at the human H4R.
Synthesis of novel histamine H4 receptor antagonists
Lane, Charlotte A.L.,Hay, Duncan,Mowbray, Charles E.,Paradowski, Michael,Selby, Matthew D.,Swain, Nigel A.,Williams, David H.
, p. 1156 - 1159 (2012/03/11)
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.
NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS
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Page/Page column 138, (2011/12/02)
Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
