35849-41-3

Basic information

• Product Name: N-Formyl-4-[bis(2-chloroethyl)amino]-L-phenylalanine
• Synonyms: 4-[Bis(2-chloroethyl)amino]-N-formyl-L-phenylalanine;N-Formyl-4-[bis(2-chloroethyl)amino]-L-phenylalanine;N-Formyl-L-p-sarcolysin
• CAS NO: 35849-41-3
• Molecular Formula: C₁₄H₁₈Cl₂N₂O₃
• Molecular Weight: 333.24
• Mol File: 35849-41-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 580.1°Cat760mmHg
• Flash Point: 304.6°C
• Appearance: /
• Density: 1.4160 (rough estimate)
• Refractive Index: 1.6140 (estimate)
• CAS DataBase Reference: N-Formyl-4-[bis(2-chloroethyl)amino]-L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Formyl-4-[bis(2-chloroethyl)amino]-L-phenylalanine(35849-41-3)
• EPA Substance Registry System: N-Formyl-4-[bis(2-chloroethyl)amino]-L-phenylalanine(35849-41-3)

Safety Data

• Hazardous Substances Data: 35849-41-3(Hazardous Substances Data)

Usage

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. Human gastrointestinaleffects by ingestion. When heated to decomposition itemits very toxic fumes of Cl?? and NOx.

InChI:InChI=1/C14H18Cl2N2O3/c15-5-7-18(8-6-16)12-3-1-11(2-4-12)9-13(14(20)21)17-10-19/h1-4,10,13H,5-9H2,(H,17,19)(H,20,21)/t13-/m0/s1

Upstream product

• 64-18-6 formic acid 
• 148-82-3 L-PAM 

Downstream Products

• 909259-55-8 (N-Formyl-melphalanyl)-glycin-ethylester 
• 100793-08-6 N-Formyl-p--L-phenylalanin-amid 
• 18067-07-7 ethyl (S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoate 

Relevant articles and documents

Design and synthesis of chromone-nitrogen mustard derivatives and evaluation of anti-breast cancer activity

Chromone has emerged as one of the most important synthetic scaffolds for antitumor activity, which promotes the development of candidate drugs with better activity. In this study, a series of nitrogen mustard derivatives of chromone were designed and syn

Novel hybrids of natural oridonin-bearing nitrogen mustards as potential anticancer drug candidates

A series of novel hybrids from natural product oridonin and nitrogen mustards were designed and synthesized to obtain more efficacious and less toxic antitumor agents. The antiproliferative evaluation showed that most conjugates were more potent than their parent compounds oridonin and clinically used nitrogen mustards against four human cancer cell lines (K562, MCF-7, Bel-7402, and MGC-803). Furthermore, the representative compounds 16a-c exhibited antiproliferative activities against the multidrug resistant cell lines (SW620/AD300 and NCI-H460/MX20). It was shown that the most effective compound 16b possesses a strong inhibitory activity with an IC50 value 21-fold lower than that of oridonin in MCF-7 cells and also exhibits selective cytotoxicity toward the cancer cells. Intriguingly, compound 16b has been demonstrated to significantly induce apoptosis and affect cell cycle progression in human hepatoma Bel-7402 cells.