35875-75-3

Basic information

• Product Name: Benzoxazole, 2-(4-chlorophenyl)-5-methyl-
• CAS NO: 35875-75-3
• Molecular Formula: C14H10ClNO
• Molecular Weight: 243.692
• Mol File: 35875-75-3.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: Benzoxazole, 2-(4-chlorophenyl)-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoxazole, 2-(4-chlorophenyl)-5-methyl-(35875-75-3)
• EPA Substance Registry System: Benzoxazole, 2-(4-chlorophenyl)-5-methyl-(35875-75-3)

Safety Data

• Hazardous Substances Data: 35875-75-3(Hazardous Substances Data)

Upstream product

• 65440-81-5 O-(4-methylphenyl)hydroxylamine 
• 10531-78-9 5-methyl-1,3-benzoxazole 
• 122-01-0 4-chloro-benzoyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 95-84-1 3-amino-4-hydroxytoluene 
• 13939-06-5 molybdenum hexacarbonyl 
• 104-86-9 4-chlorobenzylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 119-33-5 4-methyl-2-nitrophenol 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 83392-36-3 methyl 3-(4-chlorophenyl)-3-oxopropanedithioate 
• 1554868-92-6 C₁₄H₁₁BrClNO 
• 108-90-7 chlorobenzene 

Relevant articles and documents

TEMPO-mediated aerobic oxidative synthesis of 2-aryl benzoxazoles via ring-opening of benzoxazoles with benzylamines

A simple and efficient TEMPO-mediated system for aerobic oxidative synthesis of 2-aryl benzoxazoles from readily available benzoxazoles and primary benzylic and hetero benzylic amines is presented in one pot. The reaction proceeds through the ring-opening of benzoxazoles and is followed by oxidative condensation with benzylamines. These metal-free, straightforward reactions worked well with a wide range of substrates, yielding moderate to good yields under mild conditions using air as an external green oxidant.

One-pot multicomponent reaction of catechols, ammonium acetate, and aldehydes for the synthesis of benzoxazole derivatives using the fe(iii)-salen complex

The Fe(III)-salen complex has been applied successfully as a catalyst for the novel, simple, efficient, and one-pot multicomponent synthesis of benzoxazole derivatives from catechols, ammonium acetate as the nitrogen source, and aldehydes (nontoxic and cheap alternatives of amines) for the first time. Using this procedure, a wide range of benzoxazoles was successfully synthesized in the presence of a catalyst in EtOH under mild conditions, and all products were obtained in excellent yields. To the best of our knowledge, this method is the first example of the multicomponent synthesis of benzoxazole derivatives using these starting materials. The notable features such as the use of air that is considered as a benign oxidant and EtOH as a green solvent, ease of product separation, readily available and inexpensive aldehydes, and mild conditions make our procedure more efficient and practical for organic synthesis. Moreover, the current protocol is successfully applied to synthesize desirable products on a large scale.

Sulfur/DABCO Promoted Reductive Coupling/Annulation Cascade Reaction between o -Hydroxy/Amino Nitrobenzenes and Benzaldehydes

Sulfur/DABCO was found to be an efficient reagent in promoting- the reductive coupling/annulation of o -nitrophenols or o -nitroanilines with benzaldehydes. This method represents a simple, straightforward, and green approach to the construction of benz-oxazoles and benzimidazoles.