35891-93-1 Usage
Description
Tocainide hydrochloride, also known as 2-amino-2',6'-propionoxyxylidide hydrochloride (Tonocard), is an analog of lidocaine. It is an orally active drug with electrophysiological properties similar to those of lidocaine. Tocainide hydrochloride has a pKa value of 7.7 and is characterized by its low hepatic clearance, suggesting a minimal first-pass effect after oral ingestion. The drug differs from lidocaine by lacking two ethyl groups, which provides some protection from first-pass hepatic elimination. Tocainide hydrochloride is hydrolyzed in a manner similar to lidocaine, but none of its metabolites are active.
Uses
Used in Pharmaceutical Industry:
Tocainide hydrochloride is used as an anti-arrhythmic drug for the treatment of myocardial depression. It helps in regulating the heart's rhythm and reducing the risk of abnormal heart contractions.
Used in Cardiovascular Applications:
Tocainide hydrochloride is used as a myocardial depressant to manage and treat various heart conditions, such as arrhythmias, by stabilizing the electrical activity within the heart muscle.
Clinical Use
Tocainide hydrochloride is classed as a IB antiarrhythmicagent and used orally to prevent or treat ventricular ectopyand tachycardia. The drug is given in 400- to 600-mgdoses every 8 hours.
Veterinary Drugs and Treatments
Veterinary experience with tocainide is limited. At this time, dogs
are the only veterinary species where enough clinical experience has
been garnered to recommend its use. It is indicated for the oral therapy
of ventricular arrhythmias, principally ventricular tachycardia
and ventricular premature complexes. In humans, response to lidocaine
can usually predict whether tocainide might be effective.
Check Digit Verification of cas no
The CAS Registry Mumber 35891-93-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,8,9 and 1 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 35891-93:
(7*3)+(6*5)+(5*8)+(4*9)+(3*1)+(2*9)+(1*3)=151
151 % 10 = 1
So 35891-93-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
35891-93-1Relevant articles and documents
Synthesis and anticonvulsant activity of some 2/3- benzoylaminopropionanilide derivatives
Uysal,Calis,Soyer
experimental part, p. 295 - 300 (2012/08/07)
In this study, the synthesis and anticonvulsant properties of sixteen 2/3-benzoylaminopropionanilide derivatives were described. Molecular design of the compounds has been based on the modification of lacosamide which is a functionalized amino acid with a novel anticonvulsant activity. The structural confirmation of the title compounds was achieved by spectral and analytical data. The anticonvulsant activity profile of synthesized compounds was determined by maximal electroshock (MES) and subcutaneous metrazole (scMet) seizure tests, whereas their neurotoxicity was examined using rotarod test. All these tests were performed in accordance with the procedures of the Antiepileptic Drug Development (ADD) program. The majority of the compounds were effective in the MES or scMet screening tests. None of the compounds showed neurotoxicity according to the rotarod test at studied doses. Most active compounds in the series were 3, 12 and 13, which bearing 2-methyl, 2-ethyl and 2-isopropyl substituent on the N-phenyl ring, respectively. Georg Thieme Verlag KG Stuttgart - New York.
Process for the preparation of α-aminoacylanilides
-
, (2008/06/13)
A novel process for the preparation of α-aminoacylanilides comprises the treatment of the corresponding α-haloacylanilides with a solution of ammonium carbamate in aqueous ammonia. The process is especially useful in the preparation of certain active cardiac antiarrhythmic agents, such as tocainide.
