35908-31-7

Basic information

• Product Name: Inosine-5'-triphosphate trisodium salt
• Synonyms: itp;trisodium inosine 5'-triphosphate;INOSINE 5''-TRIPHOSPHATE SODIUM SALT HYDRATE;Inosine-5''-triphosphoric acid trisodium salt;INOSINE 5''-TRIPHOSPHATE TRISODIUM SALT (ITP);ITP.Na3;5'-ITP 3Na;5'-ITPNa3
• CAS NO: 35908-31-7
• Molecular Formula: C10H12N4Na3O14P3
• Molecular Weight: 574.11
• EINECS: 2017-001-1
• Product Categories: Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs
• Mol File: 35908-31-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 994.9oC at 760mmHg
• Flash Point: 555.5oC
• Appearance: White/Powder
• Density: 2.63g/cm3
• Storage Temp.: −20°C
• Solubility: Methanol (Very Slightly, Heated, Sonicated), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Inosine-5'-triphosphate trisodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Inosine-5'-triphosphate trisodium salt(35908-31-7)
• EPA Substance Registry System: Inosine-5'-triphosphate trisodium salt(35908-31-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-60-37
• WGK Germany: 1
• Hazardous Substances Data: 35908-31-7(Hazardous Substances Data)

Usage

Description

Inosine-5'-triphosphate trisodium salt, also known as ITP, is a nucleotide that plays a crucial role in various biological processes and enzyme studies. It is a triphosphate derivative of the nucleoside inosine, where three phosphate groups are attached to the sugar component. ITP is involved in cellular energy transfer, signal transduction, and enzyme regulation.

Uses

Used in Enzyme Kinetics Studies:
Inosine-5'-triphosphate trisodium salt is used as a substrate for studying the kinetics of enzymes that deaminate ATP and GTP. This application helps researchers understand the rate at which these enzymes catalyze the conversion of ATP and GTP to their respective deaminated forms, providing insights into their mechanisms and potential as therapeutic targets.
Used in Enzyme Specificity Studies:
Inosine-5'-triphosphate trisodium salt is used as a substrate to study the specificity of nucleoside-5'-triphosphatase and ATPase enzymes. By examining how these enzymes interact with ITP, researchers can gain a better understanding of their substrate preferences and the factors that influence their catalytic activity.
Used in Activation Studies of ATPases and GTPases:
Inosine-5'-triphosphate trisodium salt is used to study the activation of various ATPases and GTPases. By investigating how ITP influences the activity of these enzymes, researchers can explore the role of ITP in cellular signaling and energy transfer processes.

Biochem/physiol Actions

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD).?ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.